Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13894902 | 0.88 | CTSB (0.36) | ALDH1A1MEN1KMT2AHPGDHTT | |
| SCHEMBL4108740 | 0.88 | CTSB (0.36) | ALDH1A1MEN1KMT2AHPGDHTT | |
| SCHEMBL4119289 | 0.82 | CSNK2A1 (0.34) | ALDH1A1MEN1KMT2AHPGDHTT | |
| SCHEMBL14287456 | 0.82 | RAB9A (0.42) | ALDH1A1MEN1KMT2AHPGDHTT | |
| SCHEMBL13657244 | 0.75 | RAB9A (0.39) | ALDH1A1MEN1KMT2AHPGDHTT | |
| SCHEMBL13650599 | 0.75 | RAB9A (0.43) | ALDH1A1MEN1KMT2AHPGDHTT | |
| SCHEMBL14287459 | 0.69 | RAB9A (0.42) | ALDH1A1CYP1A2CTSBNPC1RAB9A | |
| SCHEMBL4119730 | 0.69 | CDK2 (0.37) | — | |
| SCHEMBL4111647 | 0.65 | ATM (0.32) | — | |
| SCHEMBL4107784 | 0.64 | TBXAS1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064214-B1 | Pyrazolo[l,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives useful as protein kinase inhibitors | POLARIS GROUP (TW) | 2013-01-30 | — | — | EP | disclosed |
| EP-2064214-B1 | Pyrazolo[l,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives useful as protein kinase inhibitors | POLARIS GROUP (TW) | 2013-01-30 | — | — | EP | disclosed |
| US-20090247501-A1 | PROTEIN KINASE INHIBITORS | POLARIS GROUP (TW) | 2009-10-01 | — | — | US | disclosed |
| US-20090247501-A1 | PROTEIN KINASE INHIBITORS | POLARIS GROUP (TW) | 2009-10-01 | — | — | US | disclosed |
| US-20090247501-A1 | PROTEIN KINASE INHIBITORS | POLARIS GROUP (TW) | 2009-10-01 | — | — | US | disclosed |
| US-7517882-B2 | Protein kinase inhibitors | POLARIS GROUP (CN) | 2009-04-14 | — | — | US | disclosed |
| US-7517882-B2 | Protein kinase inhibitors | POLARIS GROUP (CN) | 2009-04-14 | — | — | US | disclosed |
| US-20080070893-A1 | Protein Kinase Inhibitors | POLARIS GROUP (CN) | 2008-03-20 | — | — | US | disclosed |
| US-20080070893-A1 | Protein Kinase Inhibitors | POLARIS GROUP (CN) | 2008-03-20 | — | — | US | disclosed |
| US-20080070893-A1 | Protein Kinase Inhibitors | POLARIS GROUP (CN) | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070893-A1 | Protein Kinase Inhibitors | MAP3K15, MAP3K20, MAP3K5 | ALDH1A1 4425/4885MEN1 2503/4885KMT2A 975/4885 |
| US-20090247501-A1 | PROTEIN KINASE INHIBITORS | MAP3K15, MAP3K20, MAP3K5 | ALDH1A1 4425/4885MEN1 2503/4885KMT2A 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.