Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | SENP5 | Q96HI0 | 9/20 | 0.47 |
| ▸ | SENP2 | Q9HC62 | 9/20 | 0.47 |
| ▸ | SENP1 | Q9P0U3 | 9/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4135560 | 0.90 | KDM5B (0.51) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL4130777 | 0.85 | MMP12 (0.47) | SENP5SENP2SENP1ALDH1A1USP2 | |
| SCHEMBL4125937 | 0.85 | KMT2A (0.44) | HDAC1SENP5SENP2SENP1L3MBTL1 | |
| SCHEMBL3191169 | 0.84 | PTPN2 (0.43) | HDAC1SENP5SENP2SENP1CYP2D6 | |
| SCHEMBL4120495 | 0.83 | DYRK1A (0.50) | HDAC1MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL4119836 | 0.83 | PTPN1 (0.51) | HDAC1SENP5SENP2SENP1CYP2D6 | |
| SCHEMBL4126172 | 0.82 | KDM4E (0.46) | HDAC1SENP5SENP2SENP1MEN1 | |
| SCHEMBL4126959 | 0.82 | KDM4E (0.46) | HDAC1L3MBTL1CYP2C9MEN1KMT2A | |
| SCHEMBL4138854 | 0.80 | KMT2A (0.44) | HDAC1L3MBTL1CYP2C9MEN1KMT2A | |
| SCHEMBL4127460 | 0.79 | SENP5 (0.50) | SENP5SENP2SENP1CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | HDAC1 1382/4885SENP5 2824/4885SENP2 2422/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | HDAC1 1382/4885SENP5 2824/4885SENP2 2422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.