Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 5/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410251 | 1.00 | DDB1 (0.42) | DDB1CRBNTSHRIKZF3TDP1 | |
| SCHEMBL11606116 | 0.80 | DDB1 (0.46) | DDB1CRBNTSHRIKZF3TDP1 | |
| SCHEMBL986701 | 0.80 | DDB1 (0.46) | DDB1CRBNTSHRIKZF3TDP1 | |
| SCHEMBL15930058 | 0.80 | DDB1 (0.54) | DDB1CRBNTDP1CYP1A2ALDH1A1 | |
| SCHEMBL7284377 | 0.78 | CRBN (0.55) | DDB1CRBNTSHRIKZF3TDP1 | |
| SCHEMBL410700 | 0.78 | CRBN (0.55) | DDB1CRBNTSHRIKZF3TDP1 | |
| SCHEMBL442296 | 0.78 | CRBN (0.55) | DDB1CRBNTSHRIKZF3TDP1 | |
| SCHEMBL410243 | 0.78 | CRBN (0.55) | DDB1CRBNTSHRIKZF3TDP1 | |
| Thalidomide SCHEMBL410579 | 0.72 | CRBN (0.65) | DDB1CRBNTSHRIKZF3TDP1 | |
| Thalidomide SCHEMBL411770 | 0.72 | CRBN (0.65) | DDB1CRBNTSHRIKZF3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120064004-A1 | ISOTOPOLOGUES OF THALIDOMIDE | CELGENE CORPORATION | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064004-A1 | ISOTOPOLOGUES OF THALIDOMIDE | CDK4, FKBP8, FKBP1A | DDB1 1013/4885CRBN 475/4885TSHR 1448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.