SCHEMBL4120214

SCHEMBL4120214

CNS(=O)(=O)Cc1ccc(NC2=NC(=O)C(=Cc3ccc(-c4ccccc4C#N)cc3)S2)cc1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 1/20 0.38
ALOX5 P09917 12/20 0.34
S1PR1 P21453 1/20 0.34
S1PR3 Q99500 1/20 0.34
MYC P01106 2/20 0.33
MAX P61244 1/20 0.33
WDR5 P61964 1/20 0.32
FFAR1 O14842 1/20 0.32
AKR1B1 P15121 1/20 0.32
MAPT P10636 2/20 0.32
POLB P06746 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4120209 1.00 AGTR1 (0.38) AGTR1ALOX5S1PR1S1PR3MYC
SCHEMBL4139334 0.83 ALOX5 (0.39) AGTR1ALOX5S1PR1S1PR3MYC
SCHEMBL4139330 0.83 ALOX5 (0.39) AGTR1ALOX5S1PR1S1PR3MYC
SCHEMBL4131454 0.79 ALOX5 (0.45) ALOX5MYCMAXMAPTMEN1
SCHEMBL4131451 0.79 ALOX5 (0.45) ALOX5MYCMAXMAPTMEN1
SCHEMBL4127992 0.78 ALOX5 (0.45) ALOX5MYCMAXMAPTPOLB
SCHEMBL4127994 0.78 ALOX5 (0.45) ALOX5MYCMAXMAPTPOLB
SCHEMBL4122948 0.73 ALOX5 (0.48) ALOX5
SCHEMBL4122944 0.73 ALOX5 (0.48) ALOX5
Acetic Acid SCHEMBL4128303 0.71 FFAR1 (0.40) S1PR1S1PR3FFAR1AKR1B1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors TORRENT PHARMACEUTICALS LIMITED (IN) 2009-04-02 US claimed
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors TORRENT PHARMACEUTICALS LIMITED (IN) 2009-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors PTPRF, PTPA, PTPRJ AGTR1 588/4885ALOX5 3505/4885S1PR1 3366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.