SCHEMBL4127992

SCHEMBL4127992

CCNS(=O)(=O)Cc1ccc(NC2=NC(=O)/C(=C\c3ccc(-c4ccccc4)cc3)S2)cc1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 13/20 0.45
MYC P01106 1/20 0.40
MAX P61244 1/20 0.40
HPGD P15428 2/20 0.39
POLB P06746 1/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
HTT P42858 1/20 0.36
TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4127994 1.00 ALOX5 (0.45) ALOX5MYCMAXHPGDPOLB
SCHEMBL4132443 0.80 FFAR1 (0.47) ALOX5HTT
SCHEMBL4132445 0.80 FFAR1 (0.47) ALOX5HTT
SCHEMBL4133729 0.80 PDE4B (0.49) ALOX5MEN1KMT2A
SCHEMBL4133731 0.80 PDE4B (0.49) ALOX5MEN1KMT2A
SCHEMBL4137078 0.78 PDE4B (0.45) ALOX5HTT
SCHEMBL4141289 0.78 ALOX5 (0.44) ALOX5HPGDMEN1KMT2AALDH1A1
SCHEMBL4141291 0.78 ALOX5 (0.44) ALOX5HPGDMEN1KMT2AALDH1A1
SCHEMBL4138655 0.78 ALOX5 (0.46) ALOX5POLBALDH1A1MAPT
SCHEMBL4120214 0.78 AGTR1 (0.38) ALOX5MYCMAXPOLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors TORRENT PHARMACEUTICALS LIMITED (IN) 2009-04-02 US claimed
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors TORRENT PHARMACEUTICALS LIMITED (IN) 2009-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors PTPRF, PTPA, PTPRJ ALOX5 3505/4885MYC 2793/4885MAX 4458/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.