Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21971599 | 0.78 | LMNA (0.55) | ALDH1A1SMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL7582785 | 0.77 | MEN1 (0.49) | CALM1ALDH1A1LMNATYMPMEN1 | |
| SCHEMBL28232331 | 0.77 | CALM1 (0.41) | CALM1ALDH1A1TYMPPNMTMEN1 | |
| SCHEMBL16933813 | 0.77 | IDH1 (0.44) | CALM1ALDH1A1TYMPP2RX7 | |
| SCHEMBL28403410 | 0.76 | CSNK2A1 (0.43) | CALM1ALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL11523704 | 0.74 | CALM1 (0.58) | CALM1ALDH1A1TYMPMEN1KMT2A | |
| SCHEMBL11521959 | 0.72 | CALM1 (0.55) | CALM1ALDH1A1TYMPMEN1KMT2A | |
| SCHEMBL4120436 | 0.71 | TAAR1 (0.36) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL6072548 | 0.71 | TAAR1 (0.36) | CYP3A4TAAR1P2RX7HTTGAA | |
| SCHEMBL6072587 | 0.71 | TAAR1 (0.41) | SMN1; SMN2KDM4ELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253929-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2009-10-08 | — | — | US | disclosed |
| EP-1824806-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006062476-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253929-A1 | Chemical Compounds | CYP4B1, CYP3A4, CYP1A1 | CALM1 3443/4885ALDH1A1 319/4885SMN1; SMN2 4138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.