Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3611434 | 0.81 | CYP19A1 (0.35) | — | |
| SCHEMBL22871669 | 0.78 | GPR119 (0.48) | GPR119PIK3CDUSP30PTPN2PTPN1 | |
| SCHEMBL7397405 | 0.77 | GPR119 (0.44) | GPR119PTPN2PTPN1PTPN6NR1H2 | |
| SCHEMBL15908899 | 0.76 | NR1H2 (0.41) | GPR119USP30KDM4ENR1H2 | |
| SCHEMBL45699 | 0.76 | NR1H2 (0.41) | GPR119USP30KDM4ENR1H2 | |
| SCHEMBL950789 | 0.75 | GPR119 (0.53) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL3622797 | 0.74 | POLB (0.38) | GPR119GRM5PIK3CDDTYMKESR2 | |
| SCHEMBL14814889 | 0.74 | DDB1 (0.41) | GPR119DTYMKKDM4EMAPTTHRB | |
| SCHEMBL3610705 | 0.74 | GPR119 (0.45) | GPR119PIK3CDUSP30PTPN2PTPN1 | |
| SCHEMBL27211314 | 0.73 | GRM1 (0.44) | GPR119GRM5ESR2GRM1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101558066-A | Pyrrole derivatives with antibacterial activity | ASTRAZENECA AB (SE) | 2009-10-14 | — | — | CN | disclosed |
| EP-2064209-A1 | PYRROLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | AstraZeneca AB (SE) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008020222-A1 | PYRROLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | WO | disclosed |