Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22871669 | 0.89 | GPR119 (0.48) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL950789 | 0.86 | GPR119 (0.53) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL484385 | 0.79 | GPR119 (0.45) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL25263086 | 0.78 | JAK3 (0.41) | GPR119NR1H2FPR2JAK3 | |
| SCHEMBL15908906 | 0.78 | NR1H2 (0.42) | GPR119NR1H2JAK3 | |
| SCHEMBL15908907 | 0.78 | NR1H2 (0.42) | GPR119NR1H2JAK3 | |
| SCHEMBL4121106 | 0.77 | GPR119 (0.43) | GPR119NR1H2PTPN2PTPN1PTPN6 | |
| SCHEMBL3610705 | 0.77 | GPR119 (0.45) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL45699 | 0.77 | NR1H2 (0.41) | GPR119NR1H2 | |
| SCHEMBL15908899 | 0.77 | NR1H2 (0.41) | GPR119NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746963-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025017045-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-23 | — | — | WO | disclosed |
| CN-111704613-B | Imidazole derivatives and their use as TRPV4 inhibitors | 中国人民解放军军事科学院军事医学研究院 | 2021-07-06 | — | — | CN | disclosed |
| CN-111704613-A | Imidazole derivatives and their use as TRPV4 inhibitors | 中国人民解放军军事科学院军事医学研究院 | 2020-09-25 | — | — | CN | disclosed |
| CN-1072666-C | (Azetidin-1-ylalkyl) lactams as tachykinin antagonists | PFIZER RES AND DEV CO N V S A (IE) | 2001-10-10 | — | — | CN | disclosed |
| US-5968923-A | ANTIINFLAMMATORY AGENTS, TREATMENT OF NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| CN-1154699-A | (Azetidin-1-ylalkyl) lactams as tachykinin antagonists | PFIZER LTD (IE) | 1997-07-16 | — | — | CN | disclosed |
| EP-0775132-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | Pfizer Limited (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005193-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |
| EP-0632808-A1 | ANTIVIRAL PEPTIDES | Pfizer Limited (GB) | 1995-01-11 | — | — | EP | disclosed |
| WO-1993019059-A1 | ANTIVIRAL PEPTIDES | PFIZER LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |