Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5417329 | 0.92 | ATM (0.38) | ATMHCAR2TSHRTP53EGLN1 | |
| Fumaric Acid SCHEMBL9862115 | 0.92 | ATM (0.38) | ATMHCAR2TSHRTP53EGLN1 | |
| Monomethyl Fumarate SCHEMBL5076324 | 0.89 | HCAR2 (0.57) | ATMHCAR2POLBLMNAHRH1 | |
| SCHEMBL34965 | 0.89 | — | — | |
| SCHEMBL321481 | 0.89 | TSHR (0.36) | TSHRTP53LMNASMN1; SMN2MEN1 | |
| Potassium SCHEMBL31173511 | 0.87 | — | — | |
| Ethyl Fumarate SCHEMBL2705043 | 0.87 | HCAR2 (0.62) | ATMHCAR2TSHRLMNAHRH1 | |
| Acrylic Acid Methyl Ester SCHEMBL7026929 | 0.86 | HCAR2 (0.52) | ATMHCAR2POLBLMNAHRH1 | |
| SCHEMBL17667148 | 0.85 | ATM (0.52) | ATMHCAR2TSHRTP53EGLN1 | |
| SCHEMBL2167633 | 0.85 | ATM (0.52) | ATMHCAR2TSHRTP53EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026026-B2 | Balloons made from liquid crystal polymer blends | BOSTON SCIENTIFIC SCIMED, INC. (US) | 2006-04-11 | — | — | US | claimed |
| JP-7216204-A | — | — | None | — | — | JP | disclosed |
| CN-108699412-A | Low energy surface base material adhesive composition | 东洋纺株式会社 | 2018-10-23 | — | — | CN | disclosed |
| US-20090253834-A1 | ADHESIVE COMPOSITIONS USEFUL IN FLEXIBLE CIRCUIT SUBSTRATE APPLICATIONS AND METHODS RELATING THERETO | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-10-08 | — | — | US | disclosed |
| EP-1397169-B1 | DIMENSIONALLY STABLE BALLOONS | BOSTON SCIENT LTD (BB) | 2008-09-10 | — | — | EP | disclosed |
| US-7144938-B1 | Composition comprising ionomer and polyamide | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2006-12-05 | — | — | US | disclosed |
| US-7026026-B2 | Balloons made from liquid crystal polymer blends | BOSTON SCIENTIFIC SCIMED, INC. (US) | 2006-04-11 | — | — | US | disclosed |
| US-6977103-B2 | Dimensionally stable balloons | BOSTON SCIENTIFIC SCIMED, INC. (US) | 2005-12-20 | — | — | US | disclosed |
| EP-1397169-A1 | DIMENSIONALLY STABLE BALLOONS | Boston Scientific Limited (BB) | 2004-03-17 | — | — | EP | disclosed |
| US-20030091765-A1 | Balloons made from liquid crystal polymer blends | SCIMED LIFE SYSTEMS, INC. (US) | 2003-05-15 | — | — | US | disclosed |
| WO-2003000307-A1 | DIMENSIONALLY STABLE BALLOONS | SCIMED LIFE SYSTEMS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |
| EP-1019110-B1 | BALLOONS MADE FROM LIQUID CRYSTAL POLYMER BLENDS | BOSTON SCIENT LTD (BB) | 2002-11-13 | — | — | EP | disclosed |
| US-20010043998-A1 | Dimensionally stable balloons | BOSTON SCIENTIFIC SCIMED, INC. | 2001-11-22 | — | — | US | disclosed |
| US-20010019751-A1 | Balloons made from liquid crystal polymer blends | FERRERA DAVID A (US) | 2001-09-06 | — | — | US | disclosed |
| US-6242063-B1 | Balloons made from liquid crystal polymer blends | SCIMED LIFE SYSTEMS, INC. | 2001-06-05 | — | — | US | disclosed |
| EP-1019110-A2 | BALLOONS MADE FROM LIQUID CRYSTAL POLYMER BLENDS | SciMed Life Systems, Inc. (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999012586-A2 | BALLOONS MADE FROM LIQUID CRYSTAL POLYMER BLENDS | SCIMED LIFE SYSTEMS, INC. (US) | 1999-03-18 | — | — | WO | disclosed |
| JP-H07216204-A | MOLDING MATERIAL CONTAINING PLASTIC MIXTURE COMPRISING LINEAR HIGH-MOLECULAR-WEIGHT POLYESTER AND OLEFIN COPOLYMER | HUELS AG | 1995-08-15 | — | — | JP | disclosed |