Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5417329 | 1.00 | ATM (0.38) | ATMHRH1SMN1; SMN2HTTNPC1 | |
| Maleic Acid SCHEMBL4121144 | 0.92 | ATM (0.40) | ATMHRH1SMN1; SMN2HTTNPC1 | |
| SCHEMBL75109 | 0.90 | — | — | |
| SCHEMBL17746687 | 0.88 | EPHX1 (0.36) | SMN1; SMN2HTTTSHRTP53EPHX1 | |
| SCHEMBL25894185 | 0.88 | EPHX1 (0.36) | SMN1; SMN2HTTTSHRTP53EPHX1 | |
| Acrylic Acid Methyl Ester SCHEMBL11282822 | 0.87 | HCAR2 (0.48) | ATMHRH1SMN1; SMN2HTTNPC1 | |
| Acrylic Acid SCHEMBL5144404 | 0.86 | EPHX1 (0.41) | SMN1; SMN2HTTNPC1GAALMNA | |
| SCHEMBL4165033 | 0.86 | ATM (0.49) | ATMHRH1SMN1; SMN2HTTNPC1 | |
| SCHEMBL26977331 | 0.86 | ATM (0.49) | ATMHRH1SMN1; SMN2HTTNPC1 | |
| SCHEMBL505930 | 0.86 | ATM (0.49) | ATMHRH1SMN1; SMN2HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008333-A | Thermoplastic; also containing aromatic polycarbonate, elastomeric impact modifier, alkylene acrylate copolymer | GENERAL ELECTRIC CO. (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0349747-A2 | Compatible polyphenylene ether-linear polyester blends having improved impact stength | GENERAL ELECTRIC COMPANY (US) | 1990-01-10 | — | — | EP | disclosed |