Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4102069 | 0.89 | KMT2A (0.39) | SMN1; SMN2KMT2AALDH1A1LMNAHPGDS | |
| SCHEMBL13912894 | 0.83 | KMT2A (0.40) | SMN1; SMN2KMT2AALDH1A1LMNAHPGDS | |
| SCHEMBL13902664 | 0.73 | CA1 (0.44) | — | |
| SCHEMBL16112173 | 0.72 | HPGDS (0.59) | SMN1; SMN2KMT2AALDH1A1LMNAHPGDS | |
| SCHEMBL4121707 | 0.70 | ALDH1A1 (0.37) | SMN1; SMN2KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL4043097 | 0.69 | ALDH1A1 (0.44) | SMN1; SMN2KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL12703567 | 0.68 | HCAR2 (0.67) | SMN1; SMN2KMT2APOLBTP53THRB | |
| SCHEMBL28784634 | 0.67 | LMNA (0.50) | SMN1; SMN2KMT2AALDH1A1LMNAHPGDS | |
| SCHEMBL8284647 | 0.66 | POLB (0.53) | SMN1; SMN2KMT2AALDH1A1LMNAHPGDS | |
| SCHEMBL69842 | 0.65 | KMT2A (0.64) | SMN1; SMN2KMT2AALDH1A1LMNAHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069334-A1 | Pyridazine based alpha-helix mimetics | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| WO-2009025751-A1 | PYRIDAZINE BASED ALPHA-HELIX MIMETICS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069334-A1 | Pyridazine based alpha-helix mimetics | H1-4, H1-5, H1-0 | SMN1; SMN2 4121/4885KMT2A 2822/4885ALDH1A1 3022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.