SCHEMBL4121945

SCHEMBL4121945

NC(=O)c1ccccc1C(=O)NCl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.50
ALDH1A1 P00352 4/20 0.50
MAPT P10636 2/20 0.50
HPGD P15428 2/20 0.50
TSHR P16473 1/20 0.50
HSD17B10 Q99714 1/20 0.50
METAP2 P50579 1/20 0.47
BCAT2 O15382 1/20 0.45
IRAK4 Q9NWZ3 1/20 0.44
KMT2A Q03164 1/20 0.42
ATM Q13315 1/20 0.42
PDCD1 Q15116 1/20 0.42
CD274 Q9NZQ7 1/20 0.42
POLB P06746 1/20 0.42
LMNA P02545 2/20 0.42
GAA P10253 1/20 0.41
CTNNB1 P35222 1/20 0.41
SIRT1 Q96EB6 1/20 0.41
CA1 P00915 1/20 0.40
CA9 Q16790 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30930714 0.89 POLB (0.50) KDM4EALDH1A1HPGDTSHRHSD17B10
SCHEMBL17766647 0.82 ALDH1A1 (0.54) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL27700719 0.81 ALDH1A1 (0.70) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL4967588 0.81 ALDH1A1 (0.70) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL39118 0.81 ALDH1A1 (0.70) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL1781812 0.80 ALDH1A1 (0.64) KDM4EALDH1A1MAPTHPGDKMT2A
SCHEMBL29872360 0.80 KDM4E (0.59) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL1520940 0.80 KDM4E (0.59) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL4138337 0.80 CTSD (0.55) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL27455330 0.80 ALDH1A1 (0.50) KDM4EALDH1A1HPGDTSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080299161-A1 Solid Biocide Composition and Sealed Biocide Article SANDERSON WILLIAM D 2008-12-04 US claimed
EP-1968380-A2 SOLID BIOCIDE COMPOSITION AND SEALED BIOCIDE ARTICLE Sanderson, William D. (US) 2008-09-17 EP claimed
US-7285522-B2 Adding to wash water a granule or tablet containing a hypohalite-generating compound, a bromide-releasing compound, a fluorescent whitener; increases the measured textile whitening performance versus a control by a Delta W value of greater than 3.0 THE CLOROX COMPANY (US) 2007-10-23 US claimed
WO-2007078838-A2 SOLID BIOCIDE COMPOSITION AND SEALED BIOCIDE ARTICLE SANDERSON WILLIAM D (US) 2007-07-12 WO claimed
WO-2006026048-A2 BLEACHING WITH IMPROVED WHITENING THE CLOROX COMPANY (US) 2006-03-09 WO claimed
US-20060046946-A1 Adding to wash water a granule or tablet containing a hypohalite-generating compound, a bromide-releasing compound, a fluorescent whitener; increases the measured textile whitening performance versus a control by a Delta W value of greater than 3.0 THE CLOROX COMPANY 2006-03-02 US claimed
EP-0698080-A4 LAVATORY CLEANING BLOCK BLOCK DRUG CO (US) 1998-07-29 EP claimed
US-5763376-A Lavatory cleaning block BLOCK DRUG COMPANY, INC. (US) 1998-06-09 US claimed
EP-0698080-A1 LAVATORY CLEANING BLOCK BLOCK DRUG COMPANY INC. (US) 1996-02-28 EP claimed
WO-1994026863-A1 LAVATORY CLEANING BLOCK BLOCK DRUG COMPANY, INC. (US) 1994-11-24 WO claimed
US-9580896-B2 Apparatus and method for prolonged active agent in aqueous systems HOPKINS JOHN DAVID (US) 2017-02-28 US disclosed
US-20160002904-A1 APPARATUS AND METHOD FOR PROLONGED ACTIVE AGENT DELIVERY IN AQUEOUS SYSTEMS HOPKINS JOHN DAVID (US) 2016-01-07 US disclosed
US-20090232903-A1 BIOCIDE COMPOSITIONS SANDERSON WILLIAM D 2009-09-17 US disclosed
US-20080299161-A1 Solid Biocide Composition and Sealed Biocide Article SANDERSON WILLIAM D 2008-12-04 US disclosed
EP-1968380-A2 SOLID BIOCIDE COMPOSITION AND SEALED BIOCIDE ARTICLE Sanderson, William D. (US) 2008-09-17 EP disclosed
EP-0503751-B1 Lavatory cleaning block BLOCK DRUG CO (US) 1994-11-30 EP disclosed
WO-1994026863-A1 LAVATORY CLEANING BLOCK BLOCK DRUG COMPANY, INC. (US) 1994-11-24 WO disclosed
US-5178787-A Toilets; time-release agents BLOCK DRUG COMPANY, INC. (US) 1993-01-12 US disclosed
EP-0503751-A1 Lavatory cleaning block BLOCK DRUG COMPANY INC. (US) 1992-09-16 EP disclosed
US-4159984-A METAL AND PROTON DONOR SHIONOGI & CO., LTD. (JP) 1979-07-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090232903-A1 BIOCIDE COMPOSITIONS CAT, BLVRB, BLK KDM4E 4301/4885ALDH1A1 2096/4885MAPT 3937/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.