Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615221 | 0.87 | MAP3K14 (0.41) | TGFBR1KDM4EMAP3K14TP53PIK3CD | |
| SCHEMBL409368 | 0.85 | TGFBR1 (0.42) | TGFBR1KDM4EMAP3K14TP53PIK3CD | |
| SCHEMBL413617 | 0.85 | TGFBR1 (0.50) | TGFBR1KDM4EMAP3K14TP53PIK3CD | |
| SCHEMBL409977 | 0.85 | MAP3K14 (0.45) | TGFBR1KDM4EMAP3K14PIK3CDPIK3R1 | |
| SCHEMBL407985 | 0.84 | TGFBR1 (0.46) | TGFBR1RAD52MAP3K14TP53PIK3CD | |
| SCHEMBL412286 | 0.82 | NPC1 (0.43) | TGFBR1KDM4EMAP3K14TP53PIK3CD | |
| SCHEMBL411998 | 0.82 | MAP3K14 (0.47) | TGFBR1MAP3K14PIK3CDPIK3R1 | |
| SCHEMBL413826 | 0.81 | AKT1 (0.46) | TGFBR1KDM4EMAP3K14PIK3CDPIK3R1 | |
| SCHEMBL412682 | 0.80 | MAP3K14 (0.46) | TGFBR1MAP3K14PIK3CDPIK3R1 | |
| SCHEMBL413066 | 0.80 | MAP3K14 (0.45) | TGFBR1MAP3K14PIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |