Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | STAMBP | O95630 | 1/20 | 0.38 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411997 | 0.89 | CYP1A2 (0.42) | NPC1RAB9ASMN1; SMN2CYP1A2TP53 | |
| SCHEMBL409368 | 0.86 | TGFBR1 (0.42) | TP53ALDH1A1HPGDMAP3K14KDM4E | |
| SCHEMBL413617 | 0.86 | TGFBR1 (0.50) | TP53ALDH1A1MAPTHPGDMAP3K14 | |
| SCHEMBL409977 | 0.85 | MAP3K14 (0.45) | MAP3K14KDM4EPIK3CDPIK3R1IGF1R | |
| SCHEMBL407985 | 0.85 | TGFBR1 (0.46) | TP53MAP3K14PIK3CDPIK3R1IGF1R | |
| SCHEMBL27615221 | 0.84 | MAP3K14 (0.41) | TP53ALDH1A1LMNAHPGDMAP3K14 | |
| SCHEMBL411998 | 0.83 | MAP3K14 (0.47) | MAP3K14PIK3CDPIK3R1IGF1RTGFBR1 | |
| SCHEMBL412220 | 0.82 | TGFBR1 (0.43) | TP53MAP3K14KDM4EPIK3CDPIK3R1 | |
| SCHEMBL412682 | 0.81 | MAP3K14 (0.46) | MAP3K14PIK3CDPIK3R1IGF1RTGFBR1 | |
| SCHEMBL413826 | 0.81 | AKT1 (0.46) | ALDH1A1HPGDMAP3K14KDM4EPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |