Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.34 |
| ▸ | CISD2 | Q8N5K1 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.32 |
| ▸ | PDE1A | P54750 | 2/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4126176 | 0.79 | TSHR (0.39) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL4128093 | 0.77 | TDP1 (0.43) | ALDH1A1TDP1TNFRSF1APOLBHPGD | |
| SCHEMBL4114975 | 0.76 | ALDH1A1 (0.39) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL4123787 | 0.75 | MAPT (0.41) | ALDH1A1TSHRPOLBKDM4EHSD17B10 | |
| SCHEMBL4121697 | 0.73 | MAPT (0.44) | ALDH1A1POLBSMN1; SMN2USP2HSD17B10 | |
| SCHEMBL4115886 | 0.73 | SMN1; SMN2 (0.38) | ALDH1A1TNFRSF1ACYP3A4KDM4ENOTUM | |
| SCHEMBL4134212 | 0.73 | ALDH1A1 (0.41) | ALDH1A1CISD2NOTUMSMN1; SMN2 | |
| SCHEMBL4113737 | 0.73 | TAS1R3 (0.39) | ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL4125830 | 0.73 | GAA (0.41) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL4117083 | 0.71 | PTGS1 (0.39) | ALDH1A1TNFRSF1ACYP3A4HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090192190-A1 | Benzoic Acid Derivatives that are Modulators or Agonists of GlyR | ASTRAZENECA AB (SE) | 2009-07-30 | — | — | US | disclosed |
| CN-101218201-A | Benzoic acid derivatives as GlyR modulators or agonists | ASTRAZENECA AB (SE) | 2008-07-09 | — | — | CN | disclosed |
| EP-1890993-A2 | BENZOIC ACID DERIVATIVES THAT ARE MODULATORS OR ANTAGONISTS OF GLYR | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006121390-A2 | BENZOIC ACID DERIVATIVES THAT ARE MODULATORS OR AGONISTS OF GLYR | ASTRAZENECA AB (SE) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192190-A1 | Benzoic Acid Derivatives that are Modulators or Agonists of GlyR | GLRA1, GLRB, GPBAR1 | ADRA2A 133/4885ADRA2C 203/4885ADRA1D 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.