Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 13/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433768 | 0.91 | ADRA1A (0.57) | ADRA1AHRH3L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4140037 | 0.90 | ALDH1A1 (0.59) | ADRA1AHRH3L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4130774 | 0.90 | ALDH1A1 (0.59) | ADRA1AHRH3L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4137124 | 0.90 | ADRA1A (0.59) | ADRA1AHRH3L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4134873 | 0.88 | ALDH1A1 (0.65) | ADRA1AHRH3L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4563696 | 0.88 | ADRA1A (0.54) | ADRA1AHRH3L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4130648 | 0.87 | ADRA1A (0.56) | ADRA1AHRH3L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4293818 | 0.85 | ADRA1A (0.54) | ADRA1AHRH3L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4284689 | 0.85 | ADRA1A (0.54) | ADRA1AHRH3L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4936546 | 0.85 | HRH3 (0.64) | ADRA1AHRH3ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021004-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-02-11 | — | — | EP | claimed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | claimed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | claimed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | HRH3, HRH4, HRH1 | ADRA1A 420/4885HRH3 1/4885L3MBTL3 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.