Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.51 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4140037 | 1.00 | ALDH1A1 (0.59) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL4433768 | 0.99 | ADRA1A (0.57) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL4134873 | 0.90 | ALDH1A1 (0.65) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL4123429 | 0.90 | ADRA1A (0.64) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL4563696 | 0.90 | ADRA1A (0.54) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL13648890 | 0.88 | ALDH1A1 (0.67) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL3975118 | 0.87 | ALDH1A1 (0.65) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| Hydrochloric Acid SCHEMBL3977312 | 0.87 | ALDH1A1 (0.65) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL13648899 | 0.87 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL4936557 | 0.86 | ADRA1A (0.50) | ALDH1A1KDM4EPOLBHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021004-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-02-11 | — | — | EP | claimed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | claimed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | claimed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | HRH3, HRH4, HRH1 | ALDH1A1 734/4885KDM4E 1025/4885POLB 3797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.