Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 3/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408156 | 0.76 | HDAC1 (0.47) | TDP1LTB4RLTB4R2KDM4EGLA | |
| SCHEMBL22804425 | 0.72 | TAAR1 (0.46) | TDP1LTB4RLTB4R2KDM4EGLA | |
| SCHEMBL412345 | 0.71 | L3MBTL1 (0.40) | TDP1LTB4RLTB4R2KDM4EGLA | |
| SCHEMBL2574637 | 0.70 | MEN1 (0.44) | LTB4RLTB4R2L3MBTL1KMT2AMEN1 | |
| SCHEMBL14865109 | 0.70 | MEN1 (0.40) | TDP1KMT2AMEN1POLB | |
| SCHEMBL9888384 | 0.69 | KDM4E (0.46) | TDP1KDM4EGLAL3MBTL1KMT2A | |
| SCHEMBL3574502 | 0.69 | HDAC1 (0.52) | TDP1KDM4EGLAL3MBTL1KMT2A | |
| SCHEMBL29366016 | 0.67 | KDM4E (0.41) | TDP1LTB4RLTB4R2KDM4EGLA | |
| SCHEMBL4858 | 0.67 | TAAR1 (0.47) | KDM4EGLAL3MBTL1POLBCTDSP1 | |
| SCHEMBL3615501 | 0.65 | HDAC1 (0.46) | TDP1KDM4EGLAL3MBTL1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130123275-A1 | PYRAZINE DERIVATIVES | ASTRAZENECA AB (SE) | 2013-05-16 | — | — | US | disclosed |
| US-20120022082-A1 | PYRAZINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-01-26 | — | — | US | disclosed |
| WO-2011089416-A1 | PYRAZINE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123275-A1 | PYRAZINE DERIVATIVES | IL5, BMP2, PTH1R | TDP1 3884/4885LTB4R 1399/4885LTB4R2 1936/4885 |
| US-20120022082-A1 | PYRAZINE DERIVATIVES | IL5, BMP2, PTH1R | TDP1 3884/4885LTB4R 1399/4885LTB4R2 1936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.