Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381617 | 0.80 | DDB1 (0.50) | TLR4KMT2ACA1CA2CA4 | |
| SCHEMBL15874655 | 0.80 | KDM4E (0.42) | HPGDALDH1A1TLR4SMN1; SMN2KMT2A | |
| SCHEMBL1616775 | 0.80 | KDM4E (0.42) | HPGDALDH1A1TLR4SMN1; SMN2KMT2A | |
| SCHEMBL1138156 | 0.80 | NPC1 (0.45) | ALDH1A1LMNATLR4SMN1; SMN2KMT2A | |
| SCHEMBL11840693 | 0.79 | KMT2A (0.42) | HPGDTLR4SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL11837854 | 0.78 | CA1 (0.41) | HPGDALDH1A1LMNATLR4SMN1; SMN2 | |
| SCHEMBL7542404 | 0.78 | PTGS1 (0.60) | LMNAPTGS1PTGS2KMT2AOPRK1 | |
| SCHEMBL28414141 | 0.77 | ALDH1A1 (0.49) | HPGDALDH1A1LMNATLR4SMN1; SMN2 | |
| SCHEMBL19993834 | 0.77 | LMNA (0.42) | LMNATLR4KMT2ANPC1CA1 | |
| SCHEMBL513149 | 0.77 | LMNA (0.42) | TDP1ALDH1A1LMNATLR4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111233599-B | Aromatic ring ortho-iodoalkanone and synthetic method and application thereof | 兰州大学 | 2021-07-20 | — | — | CN | disclosed |
| CN-111233599-A | Aromatic ring ortho-iodoalkanone and synthetic method and application thereof | 兰州大学 | 2020-06-05 | — | — | CN | disclosed |
| US-8436005-B2 | Macrocyclic pyrimidine derivatives | ABBOTT LABORATORIES (US) | 2013-05-07 | — | — | US | disclosed |
| US-20090253678-A1 | MACROCYCLIC PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253678-A1 | MACROCYCLIC PYRIMIDINE DERIVATIVES | DPYD, TYMS, TYMP | HPGD 380/4885TDP1 239/4885ALDH1A1 1436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.