SCHEMBL4124483

SCHEMBL4124483

O=C(O)c1ccc2cc(O)ccc2c1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.50
CA12 O43570 2/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
CA14 Q9ULX7 2/20 0.50
ALDH1A1 P00352 2/20 0.50
ALOX5 P09917 1/20 0.46
PTGS2 P35354 1/20 0.46
ESR1 P03372 4/20 0.45
ESR2 Q92731 4/20 0.45
SOS1 Q07889 1/20 0.43
MAOA P21397 1/20 0.42
HCAR2 Q8TDS4 1/20 0.42
PTPN1 P18031 2/20 0.42
LCK P06239 1/20 0.41
CDC25B P30305 1/20 0.41
HSD17B10 Q99714 2/20 0.41
LDHA P00338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL945628 0.82 PTPN1 (0.59) TSHRALDH1A1PTPN1HSD17B10CASP1
SCHEMBL3391531 0.81 LDHA (0.61) TSHRCA12CA1CA2CA7
Hydrochloric Acid SCHEMBL10957441 0.81 PTPN1 (0.57) TSHRALDH1A1PTPN1LCKHSD17B10
SCHEMBL2187409 0.80 CA12 (0.52) TSHRCA12CA1CA2CA7
SCHEMBL9274158 0.79 CA12 (0.50) TSHRCA12CA1CA2CA7
SCHEMBL4137339 0.79 CA12 (0.50) TSHRCA12CA1CA2CA7
SCHEMBL9622910 0.79 CA12 (0.50) TSHRCA12CA1CA2CA7
SCHEMBL11677598 0.78 TSHR (0.54) TSHRCA12CA1CA2CA7
SCHEMBL3541419 0.77 KDM4E (0.54) CA12CA1CA2CA7CA9
SCHEMBL472324 0.77 MCL1 (0.42) TSHRALDH1A1ESR1ESR2SOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1983020-B1 METHOD FOR MODIFICATION OF LIQUID CRYSTAL POLYMER LEF TECHNOLOGY INC (JP) 2014-05-07 EP disclosed
CN-101384651-B Method for modification of liquid crystal polymer LEF TECHNOLOGY INC 2011-11-09 CN disclosed
US-7608371-B2 Irradiating polyesters with laser beam having pulse width of 10-12 seconds or less to improve physical strength; abrasion resistance LEF TECHNOLOGY, INC. (JP) 2009-10-27 US disclosed
CN-101384651-A Method for modification of liquid crystal polymer LEF TECHNOLOGY INC (JP) 2009-03-11 CN disclosed
US-20090048362-A1 Method of Modifying Liquid Crystal Polymers LEF TECHNOLOGY, INC. (JP) 2009-02-19 US disclosed
EP-1983020-A1 METHOD FOR MODIFICATION OF LIQUID CRYSTAL POLYMER LEF Technology Inc. (JP) 2008-10-22 EP disclosed
CN-1205011-C Resin injection method UEON SEIYAKU OYO KENKYUJO KK (JP) 2005-06-08 CN disclosed
US-6656386-B2 To provide molded article having reflow- soldering heat resistance KABUSHIKI KAISHA UENO SEIYAKU OYO KENKUJO (JP) 2003-12-02 US disclosed
US-20030008979-A1 Wholly aromatic heat-stable liquid crystalline polyester resin composition with improved melt flowability KABUSHIKI KAISHA UENO SEIYAKU OYO K. 2003-01-09 US disclosed
CN-1323682-A Resin injection method UEON SEIYAKU OYO KENKYUJO KK (JP) 2001-11-28 CN disclosed
EP-0212944-B1 MELT-PROCESSABLE AROMATIC COPOLYESTER Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) 1992-04-08 EP disclosed
CN-1007063-B COPOLYESTER VENO FINE CHEMICAL IND LTD (JP) 1990-03-07 CN disclosed
US-4746721-A ENGINEERING PLASTICS KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) 1988-05-24 US disclosed
EP-0212944-A2 Melt-processable aromatic copolyester Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) 1987-03-04 EP disclosed
CN-86105004-A COPOLYESTER 1987-02-18 CN disclosed