SCHEMBL4137339

SCHEMBL4137339

Cc1c(C(=O)O)ccc2cc(O)ccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
CA14 Q9ULX7 2/20 0.50
ALDH1A1 P00352 2/20 0.50
TSHR P16473 1/20 0.50
ALOX5 P09917 1/20 0.46
PTGS2 P35354 1/20 0.46
ESR1 P03372 1/20 0.45
ESR2 Q92731 1/20 0.45
PTPN1 P18031 2/20 0.44
MYC P01106 2/20 0.44
SOS1 Q07889 1/20 0.43
MAOA P21397 1/20 0.42
SMAD3 P84022 1/20 0.42
LCK P06239 1/20 0.41
CDC25B P30305 1/20 0.41
LDHA P00338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2749203 0.82 PTPN1 (0.59) ALDH1A1PTPN1MYCTDP1MEN1
SCHEMBL3391531 0.81 LDHA (0.61) CA12CA1CA2CA7CA9
SCHEMBL8153524 0.81 KMT2A (0.46) ALDH1A1ESR1ESR2HSD17B10TDP1
SCHEMBL2354671 0.81 RXFP1 (0.51) ALDH1A1MYCTDP1MEN1MAPT
SCHEMBL2187409 0.80 CA12 (0.52) CA12CA1CA2CA7CA9
SCHEMBL9274158 0.79 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL9622910 0.79 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL4124483 0.79 TSHR (0.50) CA12CA1CA2CA7CA9
SCHEMBL23909563 0.78 PTPN1 (0.46) ALDH1A1PTPN1MYCLCKCDC25B
SCHEMBL2128646 0.78 CA12 (0.46) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113748021-A Method for producing liquid crystal polyester processed product 本州化学工业株式会社 2021-12-03 CN disclosed
EP-1983020-B1 METHOD FOR MODIFICATION OF LIQUID CRYSTAL POLYMER LEF TECHNOLOGY INC (JP) 2014-05-07 EP disclosed
US-7608371-B2 Irradiating polyesters with laser beam having pulse width of 10-12 seconds or less to improve physical strength; abrasion resistance LEF TECHNOLOGY, INC. (JP) 2009-10-27 US disclosed
US-20090048362-A1 Method of Modifying Liquid Crystal Polymers LEF TECHNOLOGY, INC. (JP) 2009-02-19 US disclosed
EP-1983020-A1 METHOD FOR MODIFICATION OF LIQUID CRYSTAL POLYMER LEF Technology Inc. (JP) 2008-10-22 EP disclosed
EP-1549598-A4 NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) CORTICAL PTY LTD (AU) 2008-01-23 EP disclosed
US-20060106102-A1 Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) Morand, Eric 2006-05-18 US disclosed
EP-1549598-A1 NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) Cortical Pty Ltd (AU) 2005-07-06 EP disclosed
WO-2003104178-A1 NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) CORTICAL PTY LTD (AU) 2003-12-18 WO disclosed
US-6656386-B2 To provide molded article having reflow- soldering heat resistance KABUSHIKI KAISHA UENO SEIYAKU OYO KENKUJO (JP) 2003-12-02 US disclosed
US-20030008979-A1 Wholly aromatic heat-stable liquid crystalline polyester resin composition with improved melt flowability KABUSHIKI KAISHA UENO SEIYAKU OYO K. 2003-01-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060106102-A1 Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) MIF, ARG1, MSR1 CA12 1448/4885CA1 2883/4885CA2 3698/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.