Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994283 | 0.86 | LMNA (0.41) | CYP1A2CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL3992644 | 0.85 | SMN1; SMN2 (0.39) | KDM4EHPGDHSD17B10ADORA2AMEN1 | |
| SCHEMBL3991929 | 0.81 | MT-CO2 (0.38) | KDM4ECYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL244726 | 0.80 | PIK3CA (0.40) | KDM4ETSHRMEN1KMT2ATHRB | |
| SCHEMBL31086578 | 0.76 | MEN1 (0.40) | KDM4EADORA2AMEN1KMT2AMAPT | |
| SCHEMBL3115454 | 0.69 | PIK3CA (0.39) | KDM4ETSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3328811 | 0.68 | PIK3CA (0.43) | KDM4EPIK3CAMAPK1MTOR | |
| SCHEMBL21263157 | 0.67 | PIK3R1 (0.46) | PIK3CAMTOR | |
| SCHEMBL17408814 | 0.67 | PIK3CA (0.39) | MEN1KMT2ASMN1; SMN2PIK3CAMAPK1 | |
| SCHEMBL3991404 | 0.67 | MAPT (0.51) | CYP1A2CYP2C19MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |