Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049091 | 0.79 | KDM4E (0.36) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL8045132 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4125343 | 0.73 | KMT2A (0.41) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4901385 | 0.70 | KDM4E (0.44) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4123024 | 0.69 | ALDH1A1 (0.36) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4903972 | 0.69 | KDM4E (0.46) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL8034133 | 0.69 | KDM4E (0.36) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4117755 | 0.67 | KDM4E (0.41) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4140662 | 0.67 | KDM4E (0.35) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4122386 | 0.66 | KDM4E (0.36) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |