Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 6/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976859 | 0.77 | TP53 (0.43) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL11335568 | 0.73 | TTR (0.53) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL11767688 | 0.72 | KDM4E (0.51) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL11786138 | 0.72 | KDM4E (0.50) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL11771663 | 0.71 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL11770613 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL11768511 | 0.70 | KDM4E (0.62) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL28320125 | 0.70 | KDM4E (0.47) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL71110 | 0.68 | TTR (0.68) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL10855390 | 0.68 | TBXAS1 (0.60) | KDM4EALDH1A1HPGDTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131468-A1 | Bis-(Sulfonylamino) Derivatives in Therapy 065 | ASTRAZENECA AB (SE) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131468-A1 | Bis-(Sulfonylamino) Derivatives in Therapy 065 | PTGER1, CYP3A5, SULT1E1 | KDM4E 1469/4885ALDH1A1 122/4885HPGD 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.