Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28794517 | 0.78 | CYP2C9 (0.64) | CYP2C9CYP2C19LMNAKDM4EALDH1A1 | |
| SCHEMBL4133223 | 0.75 | ALDH1A1 (0.56) | CYP2C9CYP2C19LMNAKDM4EALDH1A1 | |
| SCHEMBL5621395 | 0.73 | CYP2C9 (1.00) | CYP2C9CYP2C19LMNAKDM4EALDH1A1 | |
| SCHEMBL4125992 | 0.72 | PTPN1 (0.56) | KDM4EALDH1A1KMT2APTPN1PTPN2 | |
| SCHEMBL3882476 | 0.72 | CYP2C9 (0.82) | CYP2C9CYP2C19LMNAKDM4EALDH1A1 | |
| SCHEMBL7208213 | 0.71 | LMNA (1.00) | CYP2C9CYP2C19LMNAKDM4EALDH1A1 | |
| SCHEMBL27852359 | 0.70 | CYP2C9 (0.55) | CYP2C9CYP2C19LMNAKDM4EALDH1A1 | |
| SCHEMBL719808 | 0.70 | ALDH1A1 (0.53) | CYP2C9CYP2C19LMNAKDM4EALDH1A1 | |
| SCHEMBL4118771 | 0.69 | ALDH1A1 (0.67) | CYP2C9CYP2C19LMNAKDM4EALDH1A1 | |
| SCHEMBL3880856 | 0.69 | CYP2C9 (0.69) | CYP2C9CYP2C19LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | CYP2C9 2638/4885CYP2C19 2677/4885LMNA 4856/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | CYP2C9 2638/4885CYP2C19 2677/4885LMNA 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.