Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 11/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 9/20 | 0.56 |
| ▸ | DRD3 | P35462 | 8/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278989 | 0.79 | DRD4 (1.00) | DRD4ALDH1A1TSHRDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL8482360 | 0.78 | DRD4 (0.97) | DRD4ALDH1A1DRD2DRD3POLB | |
| SCHEMBL4131541 | 0.77 | CCR5 (0.52) | DRD4DRD2DRD3SIGMAR1KCNH2 | |
| SCHEMBL4138110 | 0.76 | CCR5 (0.46) | ALDH1A1TSHRPOLBKCNH2 | |
| SCHEMBL9963184 | 0.75 | ALDH1A1 (0.51) | ALDH1A1TSHRHTTL3MBTL1 | |
| SCHEMBL4146778 | 0.74 | DRD4 (0.70) | DRD4ALDH1A1DRD2DRD3SIGMAR1 | |
| SCHEMBL23136906 | 0.72 | ALDH1A1 (0.57) | ALDH1A1TSHRHTTL3MBTL1 | |
| SCHEMBL23136905 | 0.72 | ALDH1A1 (0.60) | ALDH1A1TSHRHTTL3MBTL1 | |
| SCHEMBL11100678 | 0.72 | ALDH1A1 (0.73) | DRD4ALDH1A1DRD2DRD3POLB | |
| SCHEMBL8484877 | 0.72 | DRD4 (1.00) | DRD4ALDH1A1DRD2DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209578-A1 | CHEMICAL COMPOUNDS | PFIZER INC | 2009-08-20 | — | — | US | disclosed |
| US-20090209578-A1 | CHEMICAL COMPOUNDS | PFIZER INC | 2009-08-20 | — | — | US | disclosed |
| US-20090209578-A1 | CHEMICAL COMPOUNDS | PFIZER INC | 2009-08-20 | — | — | US | disclosed |
| EP-1963303-A2 | CHEMICAL COMPOUNDS | Pfizer Limited (GB) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007066201-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007066201-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209578-A1 | CHEMICAL COMPOUNDS | CCR5, CXCR3, CXCR1 | DRD4 361/4885ALDH1A1 1442/4885TSHR 859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.