SCHEMBL4126544

SCHEMBL4126544

CC(C)(C)OC(=O)N1CCC(N(Cc2ccnc(-c3cccc(OC(F)(F)F)c3)c2)c2ccc(OC(F)(F)F)cc2)CC1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 7/20 0.50
SLC2A1 P11166 1/20 0.45
PIM1 P11309 1/20 0.42
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
ABHD6 Q9BV23 1/20 0.42
DAGLA Q9Y4D2 1/20 0.42
CCR5 P51681 2/20 0.41
HDAC1 Q13547 1/20 0.41
KCNH2 Q12809 1/20 0.40
SCN5A Q14524 1/20 0.40
SCN9A Q15858 1/20 0.40
NTRK1 P04629 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4111640 0.93 GPR119 (0.43) GPR119SLC2A1PIM1MEN1KMT2A
SCHEMBL4122387 0.90 SLC2A1 (0.54) GPR119SLC2A1MEN1KMT2AHDAC1
SCHEMBL4122503 0.88 GPR119 (0.47) GPR119SLC2A1MEN1KMT2ACCR5
SCHEMBL4126535 0.87 GPR119 (0.47) GPR119SLC2A1MEN1KMT2AABHD6
SCHEMBL4117193 0.86 SLC2A1 (0.50) GPR119SLC2A1MEN1KMT2AHDAC1
SCHEMBL4116149 0.85 SLC2A1 (0.53) GPR119SLC2A1MEN1KMT2AHDAC1
SCHEMBL4126538 0.83 GPR119 (0.44) GPR119SLC2A1MEN1KMT2ACCR5
SCHEMBL4117155 0.82 SLC2A1 (0.48) GPR119SLC2A1MEN1KMT2AHDAC1
SCHEMBL6207789 0.82 MEN1 (0.49) GPR119SLC2A1MEN1KMT2AHDAC1
SCHEMBL4123371 0.82 SLC2A1 (0.49) GPR119SLC2A1MEN1KMT2AHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090143430-A1 ERYTHROPOIETIN PRODUCTION ACCELERATOR KOWA CO., LTD. (JP) 2009-06-04 US disclosed
US-20060040986-A1 Erythropoietin production accelerator KOWA CO., LTD. (JP) 2006-02-23 US disclosed
EP-1568691-A1 ERYTHROPOIETIN PRODUCTION ACCELERATOR Kowa Co., Ltd. (JP) 2005-08-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060040986-A1 Erythropoietin production accelerator EPOR, GHRHR, ARL1 GPR119 66/4885SLC2A1 3455/4885PIM1 2874/4885
US-20090143430-A1 ERYTHROPOIETIN PRODUCTION ACCELERATOR EPOR, GHRHR, ARL1 GPR119 66/4885SLC2A1 3455/4885PIM1 2874/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.