Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 7/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CALML3 | P27482 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 3/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412083 | 0.91 | TDO2 (0.40) | TDO2CYP2C9CYP2C19MAOAMAOB | |
| SCHEMBL411622 | 0.89 | CYP2E1 (0.40) | CYP2E1GRM5CYP2C9CYP2C19MAOA | |
| SCHEMBL412774 | 0.89 | CYP2E1 (0.41) | CYP2E1GRM5CYP2C9CYP2C19MAOA | |
| SCHEMBL411080 | 0.88 | TDO2 (0.40) | CYP2E1TDO2GRM5CYP2C9CYP2C19 | |
| SCHEMBL463342 | 0.85 | CYP2E1 (0.57) | CYP2E1TDO2CYP2C9CYP2C19MAOA | |
| SCHEMBL412820 | 0.85 | TDO2 (0.46) | CYP2E1TDO2CYP2C9CYP2C19MAOA | |
| SCHEMBL411619 | 0.84 | GRM2 (0.40) | TDO2GRM5CALML3GRM2 | |
| SCHEMBL412657 | 0.84 | CALML3 (0.51) | CYP2C9CYP2C19MAOAMAOBCALML3 | |
| SCHEMBL13942427 | 0.82 | CYP2E1 (0.37) | CYP2E1CYP2C9CYP2C19MAOAMAOB | |
| SCHEMBL5945098 | 0.82 | CYP2E1 (0.37) | CYP2E1CYP2C9CYP2C19MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065170-A1 | Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections | MICURX PHARMACEUTICALS, INC. (KY) | 2012-03-15 | — | — | US | disclosed |
| US-20120065170-A1 | Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections | MICURX PHARMACEUTICALS, INC. (KY) | 2012-03-15 | — | — | US | disclosed |
| WO-2012033952-A1 | 3 - PHENYL- 2 -OXO- 1, 3 -OXAZOLIDINES FOR TREATMENT OF BACTERIAL INFECTIONS | MICURX PHARMACEUTICALS, INC. (KY) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065170-A1 | Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections | NISCH, SI, VIP | CYP2E1 352/4885TDO2 183/4885GRM5 4129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.