Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222985 | 0.83 | NPY5R (0.39) | — | |
| SCHEMBL4121389 | 0.81 | MAPT (0.42) | HSD11B1HTR2AHTR2CHRH1HTR2B | |
| SCHEMBL1223475 | 0.76 | HSD11B1 (0.50) | HSD11B1HSD11B2 | |
| SCHEMBL1223177 | 0.76 | HSD11B1 (0.61) | HSD11B1HSD11B2 | |
| SCHEMBL12934959 | 0.76 | HSD11B1 (0.47) | HSD11B1HTR2AHTR2CHRH1HTR2B | |
| SCHEMBL4119925 | 0.74 | KDM4E (0.44) | HSD11B1HTR2AHTR2CHRH1HTR2B | |
| SCHEMBL12935704 | 0.71 | HSD11B1 (0.42) | HSD11B1HTR2AHTR2CHRH1HTR2B | |
| SCHEMBL12935400 | 0.70 | KDM4E (0.43) | MAPK1 | |
| SCHEMBL1222272 | 0.70 | HSD11B1 (0.49) | HSD11B1USP2HSD11B2OPRL1 | |
| SCHEMBL12935781 | 0.70 | KDM4E (0.42) | OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064187-A2 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Vitae Pharmaceuticals, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008024497-A2 | INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2008-02-28 | — | — | WO | disclosed |