Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121389 | 0.83 | MAPT (0.42) | SLC18A3HSD11B1ALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL12934959 | 0.82 | HSD11B1 (0.47) | SLC18A3HSD11B1USP2OPRM1OPRL1 | |
| SCHEMBL12065337 | 0.81 | MAOA (0.46) | KDM4ESLC18A3SIGMAR1OPRM1OPRL1 | |
| SCHEMBL3991405 | 0.78 | SIGMAR1 (0.53) | SLC18A3HSD11B1SIGMAR1HTR2AHTR2C | |
| SCHEMBL29391669 | 0.78 | MAOA (0.48) | KDM4ESLC18A3SIGMAR1 | |
| SCHEMBL17383970 | 0.78 | MAOA (0.48) | KDM4ESLC18A3SIGMAR1 | |
| SCHEMBL12935704 | 0.78 | HSD11B1 (0.42) | HSD11B1USP2OPRM1OPRL1OPRK1 | |
| SCHEMBL4115045 | 0.76 | HSD11B1 (0.41) | KDM4ETDP1SLC18A3HSD11B1ALDH1A1 | |
| SCHEMBL1222272 | 0.75 | HSD11B1 (0.49) | HSD11B1USP2SIGMAR1OPRM1OPRL1 | |
| SCHEMBL4128536 | 0.74 | HSD11B1 (0.39) | HSD11B1USP2OPRL1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064187-A2 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Vitae Pharmaceuticals, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008024497-A2 | INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2008-02-28 | — | — | WO | disclosed |