Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 9/20 | 0.38 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791324 | 0.92 | CCR2 (0.45) | CCR2MCHR2KCNH2USP2CYP3A4 | |
| SCHEMBL3782902 | 0.88 | KCNH2 (0.39) | CCR2MCHR2GLSGAASMN1; SMN2 | |
| SCHEMBL3786892 | 0.86 | CCR2 (0.36) | CCR2GLSGAASMN1; SMN2KCNH2 | |
| SCHEMBL3788446 | 0.85 | GLS (0.42) | CCR2MCHR2GLSKCNH2USP2 | |
| SCHEMBL3786528 | 0.85 | WNT1 (0.40) | CCR2MCHR2GLSKCNH2WNT1 | |
| SCHEMBL3781517 | 0.84 | DRD4 (0.46) | CCR2 | |
| SCHEMBL3785872 | 0.84 | CCR2 (0.38) | CCR2GLSGAASMN1; SMN2KCNH2 | |
| SCHEMBL3784437 | 0.84 | CCR2 (0.35) | CCR2MCHR2GLSGAASMN1; SMN2 | |
| SCHEMBL3787852 | 0.82 | CCR2 (0.37) | CCR2GLSGAASMN1; SMN2KCNH2 | |
| SCHEMBL4139060 | 0.82 | KLKB1 (0.37) | CCR2GLSGAASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076404-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2009-06-18 | — | — | WO | claimed |
| WO-2009076404-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2009-06-18 | — | — | WO | disclosed |