Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4131379 | 1.00 | CA1 (0.44) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL8617 | 0.85 | — | — | |
| Indene SCHEMBL29350094 | 0.85 | — | — | |
| Indene SCHEMBL8336138 | 0.85 | CA1 (0.55) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL1053919 | 0.84 | CA1 (0.47) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL21494586 | 0.84 | CA1 (0.47) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL23071394 | 0.83 | CA1 (0.53) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL1054910 | 0.83 | CA1 (0.53) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL2967405 | 0.83 | CA1 (0.53) | CA1CA2CYP2D6CYP2C19PARP1 | |
| Indene SCHEMBL7153004 | 0.83 | CA1 (0.53) | CA1CA2CYP2D6CYP2C19PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896391-B1 | COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY | UNIV BAYLOR (US) | 2015-08-12 | — | — | EP | disclosed |
| US-8394859-B2 | Combretastatin analogs with tubulin binding activity | BAYLOR UNIVERSITY (US) | 2013-03-12 | — | — | US | disclosed |
| US-20090075943-A1 | Combretastatin Analogs with Tubulin Binding Activity | BAYLOR UNIVERSITY | 2009-03-19 | — | — | US | disclosed |
| US-7429681-B2 | Combretastatin analogs with tubulin binding activity | BAYLOR UNIVERSITY (US) | 2008-09-30 | — | — | US | disclosed |
| EP-1896391-A2 | COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY | Baylor University (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20060293394-A1 | Combretastatin analogs with tubulin binding activity | BAYLOR UNIVERSITY | 2006-12-28 | — | — | US | disclosed |
| WO-2006138427-A2 | COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY | BAYLOR UNIVERSITY (US) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293394-A1 | Combretastatin analogs with tubulin binding activity | TUBB, TUBB3, TUBB1 | CA1 3095/4885CA2 2363/4885CYP2D6 4771/4885 |
| US-20090075943-A1 | Combretastatin Analogs with Tubulin Binding Activity | TUBB, TUBB3, TUBB1 | CA1 3095/4885CA2 2363/4885CYP2D6 4771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.