Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 5/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119888 | 0.87 | NTRK1 (0.44) | NTRK1POLBGRM5LMNA | |
| SCHEMBL4126845 | 0.78 | PTPN1 (0.44) | PTPN1PTPRCPTPN2LMNA | |
| SCHEMBL4119836 | 0.74 | PTPN1 (0.51) | PTPN1PTPN2 | |
| SCHEMBL4125811 | 0.74 | PTPN1 (0.55) | PTPN1PTPRCPTPN2 | |
| SCHEMBL4120133 | 0.74 | PTPN1 (0.49) | PTPN1PTPRCPTPN2 | |
| SCHEMBL4121439 | 0.74 | PTPN1 (0.43) | PTPN1PTPRCPTPN2 | |
| SCHEMBL4126207 | 0.74 | PTPN1 (0.62) | PTPN1PTPRCPTPN2 | |
| SCHEMBL4120616 | 0.74 | RAB9A (0.51) | POLBLMNA | |
| SCHEMBL4132071 | 0.74 | PTPN1 (0.42) | PTPN1PTPRCPTPN2 | |
| SCHEMBL4121383 | 0.74 | ALDH1A1 (0.45) | PTPN1PTPRCPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885NTRK1 1724/4885POLB 3952/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885NTRK1 1724/4885POLB 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.