SCHEMBL4132569

SCHEMBL4132569

COc1ccc(Cn2nnnc2S)cc1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.53
PKM P14618 1/20 0.53
GAA P10253 4/20 0.49
TSHR P16473 3/20 0.49
ALOX15 P16050 2/20 0.49
POLB P06746 1/20 0.48
ERCC5 P28715 1/20 0.48
FEN1 P39748 1/20 0.48
MAPT P10636 4/20 0.47
KDM4E B2RXH2 3/20 0.47
TDP1 Q9NUW8 2/20 0.47
HTT P42858 2/20 0.46
LMNA P02545 1/20 0.46
TOP2A P11388 1/20 0.45
CMA1 P23946 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27573199 0.83 CMA1 (0.51) ALDH1A1PKMGAAMAPTKDM4E
SCHEMBL1768224 0.82 ALDH1A1 (0.54) ALDH1A1PKMGAATSHRALOX15
SCHEMBL7684043 0.82 ALDH1A1 (0.54) ALDH1A1PKMGAATSHRALOX15
SCHEMBL19732308 0.82 ALDH1A1 (0.54) ALDH1A1PKMGAATSHRALOX15
SCHEMBL10566633 0.82 SIGMAR1 (0.45) ALDH1A1PKMTSHRALOX15POLB
SCHEMBL7433479 0.81 ALDH1A1 (0.53) ALDH1A1PKMGAATSHRALOX15
SCHEMBL4631721 0.81 ALDH1A1 (0.53) ALDH1A1PKMGAATSHRALOX15
SCHEMBL7148471 0.79 ALDH1A1 (0.62) ALDH1A1PKMGAATSHRALOX15
SCHEMBL19726570 0.78 ALDH1A1 (0.51) ALDH1A1PKMGAATSHRALOX15
SCHEMBL1768222 0.78 ALDH1A1 (0.51) ALDH1A1PKMGAATSHRALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6620580-B2 Photographic element comprising a support bearing a blue light sensitive record containing at least three layers having different levels of light sensitivity arranged in the order slowest to fastest with the slowest layer closest to the EASTMAN KODAK COMPANY 2003-09-16 US claimed
US-20030143498-A1 Color negative element containing triple-coated blue record and method of imaging using same EASTMAN KODAK COMPANY 2003-07-31 US claimed
EP-0191621-A2 Dopamine-bêta-hydroxylase inhibitors SMITHKLINE BECKMAN CORPORATION (US) 1986-08-20 EP claimed
WO-2025021868-A1 TRAF2 INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) 2025-01-30 WO disclosed
WO-2017093543-A2 ANTI-BACTERIAL COMPOUNDS AUSPHERIX LIMITED (GB) 2017-06-08 WO disclosed
US-20090181942-A1 TRICYCLIC COMPOUNDS DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-07-16 US disclosed
EP-1939205-A1 TRICYCLIC COMPOUND Daiichi Sankyo Company, Limited (JP) 2008-07-02 EP disclosed
EP-1312978-A1 Color negative element containing triple-coated blue record and method of imaging using same EASTMAN KODAK COMPANY (US) 2003-05-21 EP disclosed
EP-1016914-B1 Photographic element containing pyrazolone pug releasing coupler and imaging process employing same EASTMAN KODAK CO (US) 2002-02-27 EP disclosed
US-6153369-A CONTAINING A 4-ARYLOXYPYRAZOL-5-ONE COUPLER EASTMAN KODAK COMPANY (US) 2000-11-28 US disclosed
EP-1016914-A1 Photographic element containing pyrazolone pug releasing coupler and imaging process employing same EASTMAN KODAK COMPANY (US) 2000-07-05 EP disclosed
US-4912024-A Mixture of couplers EASTMAN KODAK COMPANY (US) 1990-03-27 US disclosed
EP-0348134-A2 Photographic materials having releasable compounds EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-12-27 EP disclosed
EP-0348139-A2 Photograhic materials and process EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-12-27 EP disclosed
EP-0347850-A2 Photographic material having combination of releasable compounds EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-12-27 EP disclosed
US-4810811-A CHEMICAL INTERMEDIATES SMITHKLINE BECKMAN CORPORATION (US) 1989-03-07 US disclosed
US-4707488-A HYPOTENSIVE AGENTS SMITHKLINE BECKMAN CORPORATION (US) 1987-11-17 US disclosed
US-4663461-A Process for preparing 1-H-tetrazole-5-thiols AMERICAN HOME PRODUCTS CORPORATION (US) 1987-05-05 US disclosed
EP-0191621-A2 Dopamine-bêta-hydroxylase inhibitors SMITHKLINE BECKMAN CORPORATION (US) 1986-08-20 EP disclosed
US-4526978-A Process for preparing 1-H-tetrazole-5-thiols and intermediate compounds AMERICAN HOME PRODUCTS CORPORATION (US) 1985-07-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181942-A1 TRICYCLIC COMPOUNDS FDFT1, COASY, HMGCR ALDH1A1 1587/4885PKM 2660/4885GAA 922/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.