Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.59 |
| ▸ | HTR1B | P28222 | 10/20 | 0.59 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | MPO | P05164 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4137757 | 0.99 | HTR1D (0.58) | HTR1DHTR1BHTR6MPOHTR2A | |
| SCHEMBL12305093 | 0.86 | NOS3 (0.65) | HTR1DHTR1BHTR6MPONOS3 | |
| Hydrochloric Acid SCHEMBL1122135 | 0.85 | NOS3 (0.64) | HTR1DHTR1BHTR6MPONOS3 | |
| SCHEMBL1122436 | 0.83 | NOS3 (0.55) | HTR1DHTR1BHTR6HTR2ANOS3 | |
| Hydrochloric Acid SCHEMBL3416444 | 0.83 | NOS3 (0.54) | HTR1DHTR1BHTR6HTR2ANOS3 | |
| SCHEMBL3379557 | 0.81 | NOS3 (0.66) | HTR1DHTR1BHTR6HTR2ANOS3 | |
| SCHEMBL12305193 | 0.81 | NOS3 (0.66) | HTR1DHTR1BHTR6HTR2ANOS3 | |
| SCHEMBL1122143 | 0.81 | NOS3 (0.66) | HTR1DHTR1BHTR6HTR2ANOS3 | |
| SCHEMBL1121983 | 0.81 | NOS3 (0.60) | HTR1DHTR1BHTR6MPOHTR2A | |
| Hydrochloric Acid SCHEMBL3381600 | 0.81 | NOS3 (0.65) | HTR1DHTR1BHTR6HTR2ANOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101910157-B | Indole compounds and methods of treating visceral pain | NEURAXON INC | 2014-05-07 | — | — | CN | disclosed |
| US-8673909-B2 | Indole compounds and methods for treating visceral pain | NEURAXON, INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-8673909-B2 | Indole compounds and methods for treating visceral pain | NEURAXON, INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-8673909-B2 | Indole compounds and methods for treating visceral pain | NEURAXON, INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-20090192157-A1 | INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN | NEURAXON, INC. (CA) | 2009-07-30 | — | — | US | disclosed |
| US-20090192157-A1 | INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN | NEURAXON, INC. (CA) | 2009-07-30 | — | — | US | disclosed |
| US-20090192157-A1 | INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN | NEURAXON, INC. (CA) | 2009-07-30 | — | — | US | disclosed |
| WO-2009062319-A1 | INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN | NEURAXON, INC. (CA) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192157-A1 | INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN | TPH1, NOS1, IDO1 | HTR1D 6/4885HTR1B 7/4885HTR6 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.