Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL819687 | 0.81 | TRPA1 (0.51) | SMN1; SMN2HIF1ACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8765451 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2HIF1ACYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1633683 | 0.78 | CYP1A2 (0.44) | SMN1; SMN2HIF1ACYP2C9CYP2C19ALDH1A1 | |
| Bromide SCHEMBL1634841 | 0.76 | CYP1A2 (0.42) | SMN1; SMN2HIF1ACYP2C9CYP2C19ALDH1A1 | |
| Butyric Acid SCHEMBL29700570 | 0.73 | TRPA1 (0.44) | SMN1; SMN2HIF1ACES1CYP2C9CYP2C19 | |
| SCHEMBL29293841 | 0.71 | TRPA1 (0.47) | TSHRCYP2C9CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL3914609 | 0.71 | CYP2D6 (0.33) | TSHRCYP2C9CYP2C19CYP2D6CHRM1 | |
| SCHEMBL15619547 | 0.71 | SMN1; SMN2 (0.44) | CPA1TSHRSMN1; SMN2HIF1ACES1 | |
| Trifluoroacetic Acid SCHEMBL14738207 | 0.71 | SMN1; SMN2 (0.49) | CPA1TSHRSMN1; SMN2HIF1ACES1 | |
| SCHEMBL3632920 | 0.71 | CYP1A2 (0.55) | CPA1CES1CYP1A2CPB1CPA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131384-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS | SYNDEXA PHARMACEUTICALS CORPORATION (US) | 2009-05-21 | — | — | US | disclosed |
| EP-2001897-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS | Syndexa Pharmaceuticals Corporation (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007111994-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS | SYNDEXA PHARMACEUTICALS CORPORATION (US) | 2007-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131384-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS | NR1H3, NR1H2, SREBF1 | CPA1 3589/4885TSHR 4546/4885SMN1; SMN2 4422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.