Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 2/20 | 0.30 |
| ▸ | GABRD | O14764 | 2/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.30 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL2583100 | 0.79 | ALDH1A1 (0.67) | ALDH1A1LMNAHSD17B10TP53 | |
| Lactic Acid SCHEMBL28287557 | 0.77 | ALDH1A1 (0.64) | ALDH1A1LMNAHSD17B10TP53 | |
| Alcohol SCHEMBL4128420 | 0.77 | KDM6B (0.32) | KDM6BKDM5CEGLN1PHF8KDM2A | |
| Succinic Acid SCHEMBL15323172 | 0.75 | EGLN1 (0.43) | ALDH1A1LMNAHSD17B10KDM6BKDM5C | |
| Butane SCHEMBL7832973 | 0.75 | FFAR3 (0.44) | ALDH1A1LMNAHSD17B10KDM6BKDM5C | |
| Ethyl Acetate SCHEMBL3525681 | 0.75 | LMNA (0.61) | ALDH1A1LMNAHSD17B10KDM6BKDM5C | |
| SCHEMBL4377797 | 0.75 | LMNA (0.47) | LMNAKDM6BKDM5CEGLN1PHF8 | |
| SCHEMBL28055752 | 0.73 | LMNA (0.45) | LMNAKDM6BKDM5CEGLN1PHF8 | |
| Ethyl Acetate SCHEMBL11140992 | 0.72 | ALDH1A1 (0.56) | ALDH1A1LMNAHSD17B10KDM6BKDM5C | |
| Lactic Acid SCHEMBL8827900 | 0.72 | TP53 (0.44) | ALDH1A1LMNATP53KDM6BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041293-A2 | ETHANOL PRODUCTION IN NON-RECOMBINANT HOSTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008018930-A2 | ETHANOL PRODUCTION IN NON-RECOMBINANT HOSTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2008-02-14 | — | — | WO | disclosed |