Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Desogestrel. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 6/20 | 1.00 |
| ▸ | SHBG | P04278 | 8/20 | 1.00 |
| ▸ | ESR1 | P03372 | 6/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 6/20 | 1.00 |
| ▸ | AR | P10275 | 4/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 3/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 1.00 |
| ▸ | CCKBR | P32239 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desogestrel SCHEMBL20353079 | 1.00 | SHBG (1.00) | SHBGPGRESR1SLC6A4AR | |
| Desogestrel SCHEMBL14071563 | 1.00 | SHBG (1.00) | SHBGPGRESR1SLC6A4AR | |
| Desogestrel SCHEMBL13575760 | 1.00 | SHBG (1.00) | SHBGPGRESR1SLC6A4AR | |
| Desogestrel SCHEMBL28425701 | 0.95 | SHBG (0.90) | SHBGPGRESR1SLC6A4AR | |
| Etonogestrel SCHEMBL14941286 | 0.92 | SHBG (0.87) | SHBGPGRESR1SLC6A4AR | |
| Desogestrel SCHEMBL8853428 | 0.91 | SHBG (0.82) | SHBGPGRESR1SLC6A4AR | |
| SCHEMBL11335079 | 0.89 | SHBG (0.79) | SHBGPGRESR1SLC6A4AR | |
| SCHEMBL10933534 | 0.89 | SHBG (0.79) | SHBGPGRESR1SLC6A4AR | |
| Etonogestrel SCHEMBL8731710 | 0.88 | PGR (0.79) | SHBGPGRESR1SLC6A4AR | |
| SCHEMBL16421288 | 0.87 | PGR (0.76) | SHBGPGRESR1SLC6A4AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 11117 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4440706-B1 | COMPOSITIONS FOR PROMOTING HAIR GROWTH | ESTETRA SRL (BE) | 2026-04-29 | — | — | EP | claimed |
| US-12594237-B2 | Mucoadhesive gel composition | Viramal Limited (GB) | 2026-04-07 | — | — | US | claimed |
| US-20260090995-A1 | ORODISPERSIBLE DOSAGE UNIT CONTAINING AN ESTETROL COMPONENT | ESTETRA SRL (BE) | 2026-04-02 | — | — | US | claimed |
| US-20260053736-A1 | LONG ACTING DRUG DELIVERY DEVICE AND ITS USE IN CONTRACEPTION | BAYER OY (FI) | 2026-02-26 | — | — | US | claimed |
| EP-4463570-B1 | METHOD FOR HORMONE OR DRUG SCREENING IN A TISSUE SAMPLE | ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) | 2026-01-14 | — | — | EP | claimed |
| US-20260000613-A1 | INJECTABLE CONTROLLED-RELEASE FORMULATIONS OF PROGESTOGEN DRUGS | FORDOZ PHARMA CORP. (US) | 2026-01-01 | — | — | US | claimed |
| EP-4643858-A1 | METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF UTERINE DISEASE | Institut National de la Santé et de la Recherche Médicale (FR) | 2025-11-05 | — | — | EP | claimed |
| EP-4637777-A1 | USE OF ESTETROL IN HEPATICALLY IMPAIRED PATIENTS | Estetra SRL (BE) | 2025-10-29 | — | — | EP | claimed |
| US-12427114-B2 | Orodispersible dosage unit containing an estetrol component | ESTETRA SRL (BE) | 2025-09-30 | — | — | US | claimed |
| EP-4608992-A1 | BIOMARKERS FOR THE DIAGNOSIS OF DISEASES OR DISORDERS OF THE FEMALE REPRODUCTIVE TRACT | Hera Biotech, Inc. (US) | 2025-09-03 | — | — | EP | claimed |
| EP-0322020-A1 | Pharmaceutical dosage unit for treating climacteric complaints and osteoporosis | AKZO N.V. (NL) | 1989-06-28 | — | — | EP | claimed |
| EP-0309263-A2 | Hormone composition and use | JENCAP RESEARCH LIMITED (CA) | 1989-03-29 | — | — | EP | claimed |
| EP-0300523-A1 | Pharmaceutical dosage unit for the prevention or treatment of climacteric complaints | AKZO N.V. (NL) | 1989-01-25 | — | — | EP | claimed |
| US-4794119-A | Aqueous crystalline suspension of steroid glycoesters | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-12-27 | — | — | US | claimed |
| WO-1988000469-A1 | COMBINATION DOSAGE FORM FOR PRE-MENOPAUSAL WOMEN | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-28 | — | — | WO | claimed |
| EP-0253607-A1 | Combination dosage form for premenopausal women | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-20 | — | — | EP | claimed |
| EP-0136781-A2 | Treatment of endometriosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-04-10 | — | — | EP | claimed |
| EP-0036229-B1 | MULTI-PHASE COMBINATION-TYPE SEQUENTIAL PREPARATION FOR ORAL CONTRACEPTION AND METHOD OF ORAL CONTRACEPTION | AKZO N.V. (NL) | 1985-01-23 | — | — | EP | claimed |
| US-4378356-A | TABLETS WHOSE CONCENTRATION OF GESTAGEN AND OESTROGEN VARY DURING CYCLE | AKZON N.V. (NL) | 1983-03-29 | — | — | US | claimed |
| EP-0036229-A1 | Multi-phase combination-type sequential preparation for oral contraception and method of oral contraception | AKZO N.V. (NL) | 1981-09-23 | — | — | EP | claimed |