SCHEMBL4134231

SCHEMBL4134231

CN(C)c1ccc(-c2ccc(F)cc2F)nc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.43
KCNH2 Q12809 2/20 0.42
KMO O15229 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
CASP3 P42574 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39
OXTR P30559 1/20 0.38
AVPR1A P37288 1/20 0.38
KMT2A Q03164 2/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
GRM2 Q14416 2/20 0.37
ALPL P05186 1/20 0.37
GABRG2 P18507 2/20 0.36
GABRB3 P28472 2/20 0.36
GABRA5 P31644 2/20 0.36
GABRA3 P34903 2/20 0.36
ALOX5AP P20292 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4634936 0.93 DHODH (0.40) DHODHKCNH2KMOL3MBTL1CASP3
SCHEMBL19248543 0.81 KMO (0.47) DHODHKMOL3MBTL1CASP3SENP8
SCHEMBL30540118 0.81 KMO (0.47) DHODHKMOL3MBTL1CASP3SENP8
SCHEMBL31235723 0.80 KMO (0.43) KMONPC1RAB9AALPLMAPK14
SCHEMBL503494 0.79 KMO (0.47) KMOL3MBTL1CASP3SENP8SENP7
SCHEMBL15574132 0.78 DHODH (0.55) DHODHKMOL3MBTL1CASP3SENP8
SCHEMBL29463697 0.78 DHODH (0.55) DHODHKMOL3MBTL1CASP3SENP8
SCHEMBL30136159 0.77 DHODH (0.54) DHODHKMOL3MBTL1CASP3SENP8
SCHEMBL29752476 0.77 DHODH (0.54) DHODHKMOL3MBTL1CASP3SENP8
SCHEMBL16841437 0.75 DHODH (0.44) DHODHKMOL3MBTL1CASP3SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090200920-A1 Light-Emitting Material SOLVAY SA (BE) 2009-08-13 US disclosed
US-20090200920-A1 Light-Emitting Material SOLVAY SA (BE) 2009-08-13 US disclosed
US-20090200920-A1 Light-Emitting Material SOLVAY SA (BE) 2009-08-13 US disclosed
EP-1934302-A2 LIGHT-EMITTING MATERIAL Solvay SA (BE) 2008-06-25 EP disclosed
WO-2007042474-A2 LIGHT-EMITTING MATERIAL Solvay (Société Anonyme) (BE) 2007-04-19 WO disclosed
WO-2007042474-A2 LIGHT-EMITTING MATERIAL Solvay (Société Anonyme) (BE) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090200920-A1 Light-Emitting Material CLTB, EML4, APOL1 DHODH 3435/4885KCNH2 1483/4885KMO 1662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.