Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2452211 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTABCB1LMNAMEN1 | |
| SCHEMBL11889804 | 0.88 | PKM (0.51) | MAPTCYP2C19HTTTSHRPARP14 | |
| SCHEMBL11889803 | 0.88 | PKM (0.51) | MAPTCYP2C19HTTTSHRPARP14 | |
| SCHEMBL11889854 | 0.83 | GPR119 (0.59) | SMN1; SMN2MAPTLMNAMEN1KMT2A | |
| SCHEMBL2453979 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTLMNAMEN1KMT2A | |
| SCHEMBL2304722 | 0.82 | MAPT (0.58) | SMN1; SMN2MAPTLMNAMEN1KMT2A | |
| SCHEMBL5081454 | 0.81 | NAMPT (0.65) | SMN1; SMN2MAPTLMNAMEN1KMT2A | |
| SCHEMBL30182423 | 0.80 | MAPT (0.69) | SMN1; SMN2MAPTLMNAMEN1KMT2A | |
| SCHEMBL29803251 | 0.80 | MAPT (0.69) | SMN1; SMN2MAPTLMNAMEN1KMT2A | |
| SCHEMBL2452210 | 0.79 | PKM (0.46) | SMN1; SMN2MAPTLMNATSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799663-B1 | Modulators of HCV replication | ANGELETTI P IST RICHERCHE BIO (IT) | 2012-08-01 | — | — | EP | claimed |
| US-20090069344-A1 | Modulators of hcv replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-03-12 | — | — | US | claimed |
| EP-1799663-B1 | Modulators of HCV replication | ANGELETTI P IST RICHERCHE BIO (IT) | 2012-08-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069344-A1 | Modulators of hcv replication | EIF2AK2, IRF3, IFNAR1 | SMN1; SMN2 4644/4885MAPT 4662/4885ABCB1 2029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.