Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27173131 | 0.93 | ALDH1A1 (0.54) | CHEK1ALDH1A1TDP1L3MBTL1CYP2D6 | |
| SCHEMBL24750114 | 0.86 | ALDH1A1 (0.44) | ALDH1A1TDP1L3MBTL1CYP2D6MAPT | |
| SCHEMBL29785305 | 0.84 | ALDH1A1 (0.43) | CHEK1ALDH1A1TDP1L3MBTL1CYP2D6 | |
| SCHEMBL309725 | 0.84 | ALDH1A1 (0.43) | CHEK1ALDH1A1TDP1L3MBTL1CYP2D6 | |
| SCHEMBL16117975 | 0.84 | LMNA (0.46) | ALDH1A1TDP1L3MBTL1CYP2D6MAPT | |
| SCHEMBL6370055 | 0.84 | ALDH1A1 (0.57) | ALDH1A1TDP1L3MBTL1MAPTKDM4E | |
| SCHEMBL7257048 | 0.83 | ALDH1A1 (0.49) | ALDH1A1TDP1L3MBTL1CYP2D6MAPT | |
| SCHEMBL2087809 | 0.82 | ALDH1A1 (0.63) | ALDH1A1TDP1L3MBTL1CYP2D6MAPT | |
| SCHEMBL10778338 | 0.82 | ALDH1A1 (0.62) | ALDH1A1TDP1L3MBTL1CYP2D6MAPT | |
| SCHEMBL4290497 | 0.82 | GABRA1 (0.53) | ALDH1A1TDP1L3MBTL1CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069341-A1 | INHIBITORS OF HSP90 | CHENE PATRICK | 2009-03-12 | — | — | US | disclosed |
| CN-101027054-A | Inhibitors of HSP90 | NOVARTIS AG (CH) | 2007-08-29 | — | — | CN | disclosed |
| EP-1776110-A1 | INHIBITORS OF HSP90 | Novartis AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006010594-A1 | INHIBITORS OF HSP90 | NOVARTIS AG (CH) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069341-A1 | INHIBITORS OF HSP90 | HSP90AB1, HSP90B1, HSP90AA1 | CHEK1 346/4885ALDH1A1 2811/4885TDP1 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.