Naphthoic Acid

Naphthoic Acid

SCHEMBL4135372

CCCC(=O)O.O=C(O)c1cccc2ccccc12

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.72
NR4A2 P43354 1/20 0.72
NR4A3 Q92570 1/20 0.72
CDC25B P30305 2/20 0.59
TDP1 Q9NUW8 3/20 0.51
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
KDM4E B2RXH2 2/20 0.51
GMNN O75496 2/20 0.51
ALDH1A1 P00352 2/20 0.51
LMNA P02545 2/20 0.51
POLB P06746 2/20 0.51
MAPT P10636 2/20 0.51
HPGD P15428 2/20 0.51
MAPK1 P28482 2/20 0.51
BLM P54132 2/20 0.51
PMP22 Q01453 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
CMKLR1 Q99788 2/20 0.51
TP53 P04637 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naphthoic Acid SCHEMBL27837568 0.87 NR4A1 (0.81) NR4A1NR4A2NR4A3CDC25BTDP1
Naphthoic Acid SCHEMBL8715113 0.87 NR4A1 (0.95) NR4A1NR4A2NR4A3CDC25BTDP1
Naphthoic Acid SCHEMBL28570317 0.86 NR4A1 (0.72) NR4A1NR4A2NR4A3CDC25BTDP1
Naphthoic Acid SCHEMBL29095974 0.86 NR4A1 (0.78) NR4A1NR4A2NR4A3CDC25BTDP1
Phthalic Acid SCHEMBL30717997 0.85 ALDH1A1 (0.61) NR4A1NR4A2NR4A3CDC25BTDP1
Naphthoic Acid SCHEMBL30401620 0.85 NR4A1 (0.91) NR4A1NR4A2NR4A3CDC25BTDP1
Phthalic Acid SCHEMBL8155 0.85 ALDH1A1 (0.61) NR4A1NR4A2NR4A3CDC25BTDP1
Naphthoic Acid SCHEMBL29352220 0.85 NR4A1 (1.00) NR4A1NR4A2NR4A3CDC25BTDP1
Naphthoic Acid SCHEMBL30233567 0.85 NR4A1 (1.00) NR4A1NR4A2NR4A3CDC25BTDP1
Naphthoic Acid SCHEMBL17258 0.85 NR4A1 (1.00) NR4A1NR4A2NR4A3CDC25BTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006002031-A1 SUSTAINED RELEASE DOSAGE FORMS ANDRX CORPORATION (US) 2006-01-05 WO claimed
US-20050276849-A1 Sustained release dosage forms ANDRX CORPORATION 2005-12-15 US claimed
US-20090196924-A1 CONTROLLED-RELEASE LAMOTRIGINE FORMULATIONS DR. REDDY'S LABORATORIES LIMITED (IN) 2009-08-06 US disclosed
CN-100376634-C Cassade polymer composition with trigger response ROHM & HAAS (US) 2008-03-26 CN disclosed
CN-100338136-C Trigger corresponding compsn. ROHM & HAAS (US) 2007-09-19 CN disclosed
CN-1320077-C Trigger response compositioin ROHM & HAAS (US) 2007-06-06 CN disclosed
WO-2006002031-A1 SUSTAINED RELEASE DOSAGE FORMS ANDRX CORPORATION (US) 2006-01-05 WO disclosed
US-20050276849-A1 Sustained release dosage forms ANDRX CORPORATION 2005-12-15 US disclosed
CN-1510085-A Cassade polymer composition with trigger response 罗姆和哈斯公司 2004-07-07 CN disclosed
CN-1480488-A Trigger corresponding compsn. ������������� 2004-03-10 CN disclosed
CN-1477173-A Trigger response compositioin 罗姆和哈斯公司 2004-02-25 CN disclosed
US-4256108-A Microporous-semipermeable laminated osmotic system ALZA CORPORATION (US) 1981-03-17 US disclosed
US-4200098-A Osmotic system with distribution zone for dispensing beneficial agent ALZA CORPORATION (US) 1980-04-29 US disclosed
US-4160452-A Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina ALZA CORPORATION (US) 1979-07-10 US disclosed
US-4160020-A CELLULOSE ESTERS, CELLULOSE ETHERS ALZA CORPORATION (US) 1979-07-03 US disclosed
US-4116241-A FOR CONTROLLED ORAL ADMINISTRATION OF DRUG ALZA CORPORATION (US) 1978-09-26 US disclosed
US-4077407-A POLYSACCHARIDES ALZA CORPORATION (US) 1978-03-07 US disclosed
US-4058122-A Osmotic system with laminated wall formed of different materials ALZA CORPORATION (US) 1977-11-15 US disclosed
US-4014334-A Laminated osmotic system for dispensing beneficial agent ALZA CORPORATION (US) 1977-03-29 US disclosed
US-4008719-A Osmotic system having laminar arrangement for programming delivery of active agent ALZA CORPORATION (US) 1977-02-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090196924-A1 CONTROLLED-RELEASE LAMOTRIGINE FORMULATIONS LAMTOR3, CACNA1F, CACNA1G NR4A1 3680/4885NR4A2 3423/4885NR4A3 3083/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.