Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | AGER | Q15109 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 6/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM6A | O15550 | 1/20 | 0.44 |
| ▸ | TET3 | O43151 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413572 | 0.85 | NAPRT (0.58) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL29488337 | 0.85 | NAPRT (0.58) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL13145634 | 0.78 | KDM4E (0.57) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL126701 | 0.77 | LMNA (0.45) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL5691131 | 0.73 | KDM4E (0.78) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL107538 | 0.72 | NAPRT (0.67) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL29514689 | 0.72 | NAPRT (0.67) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL22835349 | 0.72 | KDM4E (0.50) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL28065704 | 0.72 | KDM4E (0.50) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL14529544 | 0.72 | KDM4E (0.50) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044050-A1 | NEW PYRIDINE ANALOGUES | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008004946-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |