Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 9/20 | 0.36 |
| ▸ | CASP7 | P55210 | 6/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CASP9 | P55211 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4140997 | 0.91 | USP30 (0.39) | CASP3CASP7DRD3KCNH2HRH3 | |
| SCHEMBL4136050 | 0.85 | CASP3 (0.39) | CASP3CASP7DRD2DRD3KCNH2 | |
| SCHEMBL4134993 | 0.82 | FAAH (0.38) | CYP1A2CYP3A4CYP2C9CYP11B1CYP11B2 | |
| SCHEMBL4136008 | 0.81 | DAGLA (0.41) | HRH3 | |
| SCHEMBL4130398 | 0.80 | ACVR1 (0.39) | BACE1DRD2DRD3PRMT5WDR77 | |
| SCHEMBL4133535 | 0.77 | HRH3 (0.43) | PRMT5KCNH2HRH3 | |
| SCHEMBL4144558 | 0.77 | MCHR1 (0.41) | KCNH2HRH3 | |
| SCHEMBL4139555 | 0.77 | GPR84 (0.40) | CYP1A2CYP3A4CYP2C9CYP11B1CYP11B2 | |
| SCHEMBL4143358 | 0.77 | USP30 (0.43) | CYP11B2DRD3KCNH2HRH3 | |
| SCHEMBL4141043 | 0.76 | KDM2B (0.38) | CYP1A2CYP11B1CYP11B2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | MCHARDY STANTON FURST | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | HRH3, HRH4, HRH1 | BACE1 450/4885CYP1A2 1220/4885CYP3A4 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.