Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ASPH | Q12797 | 1/20 | 0.45 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.45 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280628 | 0.85 | CNR1 (0.39) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL6719405 | 0.82 | RAB9A (0.64) | HDAC3HDAC1MLYCDALDH1A1KDM4E | |
| SCHEMBL5274599 | 0.82 | CNR1 (0.40) | HDAC3HDAC4HDAC1HDAC6KDM4E | |
| SCHEMBL4137576 | 0.77 | HTR6 (0.60) | RXFP1ALDH1A1POLBMAPTHTR6 | |
| SCHEMBL5276755 | 0.76 | CDC7 (0.45) | HDAC4RXFP1HTTNPC1MAPT | |
| SCHEMBL7006284 | 0.74 | GRIK1 (0.44) | HDAC1ALDH1A1HTTSMN1; SMN2RAB9A | |
| SCHEMBL1748251 | 0.74 | ACLY (0.50) | MAPT | |
| SCHEMBL8368711 | 0.73 | RAB9A (0.52) | HDAC3HDAC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL7835892 | 0.72 | RAB9A (0.57) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL4217232 | 0.72 | KDM6B (0.61) | HDAC6ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856075-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | Epix Delaware, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006081332-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | EPIX DELAWARE, INC. (US) | 2006-08-03 | — | — | WO | disclosed |