Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138380 | 1.00 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL4125224 | 0.86 | SLC6A2 (0.47) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL4125221 | 0.86 | SLC6A2 (0.47) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL4124163 | 0.86 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRM3SLC6A2SLC6A4 | |
| SCHEMBL4124168 | 0.86 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRM3SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL4141497 | 0.84 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRM3SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL4141432 | 0.84 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRM3SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL4141438 | 0.84 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRM3SLC6A2SLC6A4 | |
| SCHEMBL4145108 | 0.81 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRM3SLC6A2SLC6A4 | |
| SCHEMBL4142210 | 0.79 | SLC6A2 (0.41) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | PFIZER PRODUCTS INC. (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | OPRL1, HTR5A, OPRD1 | CHRNB2 1057/4885CHRNA4 433/4885CHRM2 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.