Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 18/20 | 0.56 |
| ▸ | CTSK | P43235 | 13/20 | 0.56 |
| ▸ | CTSL | P07711 | 8/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4133021 | 0.90 | CTSS (0.57) | CTSSCTSKCTSL | |
| SCHEMBL4138577 | 0.89 | CTSS (0.69) | CTSSCTSKCTSL | |
| SCHEMBL4133339 | 0.86 | CTSK (0.67) | CTSSCTSKCTSL | |
| SCHEMBL4151126 | 0.82 | CTSS (0.69) | CTSSCTSKCTSL | |
| SCHEMBL13924827 | 0.81 | CTSS (0.57) | CTSSCTSKCTSL | |
| SCHEMBL4138587 | 0.77 | CTSS (0.81) | CTSSCTSKCTSL | |
| SCHEMBL4136793 | 0.76 | CTSS (0.82) | CTSSCTSKCTSL | |
| SCHEMBL13924812 | 0.76 | CTSS (0.69) | CTSSCTSKCTSL | |
| SCHEMBL16232058 | 0.72 | CTSS (1.00) | CTSSCTSKCTSL | |
| SCHEMBL4142088 | 0.71 | CTSS (0.72) | CTSSCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054467-A1 | Pyrrolo Pyrimidines as Agents for the Inhibition of Cystein Proteases | BETSCHART CLAUDIA | 2009-02-26 | — | — | US | disclosed |
| US-7452886-B2 | Pyrrolo pyrimidines as agents for the inhibition of cystein proteases | NOVARTIS AG (CH) | 2008-11-18 | — | — | US | disclosed |
| EP-1423391-B1 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | NOVARTIS AG (CH) | 2006-05-17 | — | — | EP | disclosed |
| US-20050054851-A1 | Pyrrolo pyrimidines as agents for the inhibition of cystein proteases | NOVARTIS AG (CH) | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054851-A1 | Pyrrolo pyrimidines as agents for the inhibition of cystein proteases | CTSK, CTSS, CTSZ | CTSS 2/4885CTSK 1/4885CTSL 7/4885 |
| US-20090054467-A1 | Pyrrolo Pyrimidines as Agents for the Inhibition of Cystein Proteases | CTSK, CTSS, CTSZ | CTSS 2/4885CTSK 1/4885CTSL 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.