Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 10/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 10/20 | 0.32 |
| ▸ | CLK1 | P49759 | 9/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799071 | 0.63 | KDM4E (0.49) | DYRK1AL3MBTL1KDM4ENPC1RAB9A | |
| SCHEMBL31214345 | 0.62 | DYRK1A (0.72) | DYRK1AL3MBTL1KDM4ENPC1RAB9A | |
| SCHEMBL28186595 | 0.61 | DYRK1A (0.42) | DYRK1AL3MBTL1KDM4ENPC1RAB9A | |
| SCHEMBL838020 | 0.61 | KDM4E (0.44) | DYRK1AL3MBTL1KDM4ENPC1RAB9A | |
| SCHEMBL838517 | 0.61 | NPC1 (0.54) | L3MBTL1KDM4ENPC1RAB9AHKDC1 | |
| SCHEMBL23480172 | 0.59 | NPC1 (0.52) | DYRK1AL3MBTL1KDM4ENPC1RAB9A | |
| SCHEMBL411780 | 0.59 | NPC1 (0.44) | DYRK1AL3MBTL1KDM4ENPC1RAB9A | |
| SCHEMBL2586408 | 0.59 | ADORA2A (0.56) | DYRK1ACLK4ALDH1A1HSD17B10RIPK1 | |
| SCHEMBL31314979 | 0.58 | ALDH1A1 (0.58) | DYRK1AL3MBTL1KDM4ENPC1RAB9A | |
| SCHEMBL3396673 | 0.57 | NPC1 (0.53) | DYRK1AL3MBTL1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408769-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | Glaxo Group Limited (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |
| WO-2010106016-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2010-09-23 | — | — | WO | disclosed |