Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CHUK | O15111 | 2/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ICOSLG | O75144 | 1/20 | 0.43 |
| ▸ | ICOS | Q9Y6W8 | 1/20 | 0.43 |
| ▸ | KIF20A | O95235 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TLR3 | O15455 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531445 | 0.81 | PTGS1 (0.64) | PTGS1PTGS2TUBB1KMT2ARAB9A | |
| SCHEMBL28524519 | 0.78 | PTGS1 (0.62) | PTGS1PTGS2TUBB1KMT2AMEN1 | |
| SCHEMBL30619664 | 0.77 | NR4A2 (0.46) | ACHERAB9AJAK2MAPT | |
| SCHEMBL29587497 | 0.77 | NR4A2 (0.46) | ACHERAB9AJAK2MAPT | |
| SCHEMBL8534628 | 0.76 | PTGS1 (0.59) | PTGS1PTGS2TUBB1KMT2AMEN1 | |
| SCHEMBL2974886 | 0.76 | ALDH1A1 (0.61) | PTGS1PTGS2TUBB1PIKFYVEKMT2A | |
| SCHEMBL4135200 | 0.75 | ACHE (0.56) | PTGS2ACHEKMT2AMEN1RAB9A | |
| SCHEMBL3236462 | 0.75 | ACHE (0.47) | ACHEKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL25260242 | 0.74 | ALDH1A1 (0.58) | PTGS1PTGS2TUBB1KMT2AMEN1 | |
| SCHEMBL2972598 | 0.73 | TUBB1 (0.70) | PTGS1PTGS2TUBB1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009005672-A1 | ANTIDIABETIC AZAINDOLES AND DIAZAINDOLES | MERCK & CO., INC. (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009005672-A1 | ANTIDIABETIC AZAINDOLES AND DIAZAINDOLES | MERCK & CO., INC. (US) | 2009-01-08 | — | — | WO | disclosed |