Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 4/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 7/20 | 0.56 |
| ▸ | MET | P08581 | 4/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | TEK | Q02763 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794599 | 0.91 | FGFR2 (0.69) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL4141203 | 0.85 | FGFR2 (0.60) | FGFR2PDGFRAPDGFRBKDR | |
| SCHEMBL4575945 | 0.84 | MET (0.52) | FGFR2PDGFRAKDRMETKIT | |
| SCHEMBL25678872 | 0.84 | KDR (0.67) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL17489704 | 0.84 | PDGFRA (0.65) | FGFR2PDGFRAPDGFRBKDR | |
| SCHEMBL17361401 | 0.83 | MET (0.55) | PDGFRAKDRMETKITAXL | |
| SCHEMBL12499486 | 0.82 | FGFR2 (0.56) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL14967576 | 0.82 | MET (0.60) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL4154997 | 0.81 | PDGFRA (0.59) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL28428907 | 0.81 | PDGFRA (0.55) | FGFR2PDGFRAPDGFRBKDRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131461-A1 | Quinoline and quinoxaline derivatives as inhibitors of kinase enzymatic activity | CHROMA THERAPEUTICS LTD. (GB) | 2009-05-21 | — | — | US | disclosed |
| EP-1877383-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY | Chroma Therapeutics Limited (GB) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006117552-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY | CHROMA THERAPEUTICS LTD (GB) | 2006-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131461-A1 | Quinoline and quinoxaline derivatives as inhibitors of kinase enzymatic activity | CDK1, AURKC, CSNK1G3 | FGFR2 3819/4885PDGFRA 3858/4885PDGFRB 3487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.